PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING PHENYLPROPENE DERIVATIVE AS ACTIVE INGREDIENT

Title:

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER COMPRISING PHENYLPROPENE DERIVATIVE AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2023/229295

Kind Code:

A1

Abstract:

The present invention relates to a phenylpropene derivative, and a pharmaceutical composition for the prevention or treatment of cancer, comprising the phenylpropene derivative as an active ingredient. The phenylpropene derivative disclosed in the present specification was confirmed to have an ACC inhibitory activity involved in the inhibition mechanism of tumor proliferation and metastasis.

Inventors:

IM CHUN YOUNG (KR)
MIN SANG-HYUN (KR)
KIM NAM HUI (KR)
HWANG HEE-JONG (KR)
OH BAE JUN (KR)
HONG EUNMI (KR)
WOO SEO YEON (KR)
HAN YE RI (KR)
DO HYUN JU (KR)
JANG TAE-HO (KR)
LEE SEUL (KR)
KIM NAM DOO (KR)
LEE JEE-YOUNG (KR)
YU JI HOON (KR)
LEE HA-YEON (KR)
KIM YOUNG-KYU (KR)
PARK SANG-WOOK (KR)
SHIN SUNHYE (KR)
CHA EUNJU (KR)
HWANG JI SUN (KR)
SEO CHANG HOON (KR)
YEOM YOUNG IL (KR)
LEE DONG CHUL (KR)
PARK KYUNG CHAN (KR)
KIM CHA YEON (KR)
KOO HAN (KR)

Application Number:

PCT/KR2023/006799

Publication Date:

November 30, 2023

Filing Date:

May 18, 2023

Export Citation:

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Assignee:

DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)

International Classes:

C07C311/37; C07C211/28; C07C211/29; C07C215/48; C07C217/56; C07C219/32; C07C229/38; C07C317/32; C07D295/033; C07D317/58

Domestic Patent References:

WO2010081904A1

2010-07-22

Foreign References:

EP0527458A1

1993-02-17

Other References:

MILNE KIRSTY; SUN JIANHUI; ZAAL ESTHER A.; MOWAT JENNA; CELIE PATRICK H.N.; FISH ALEXANDER; BERKERS CELIA R.; FORLANI GIUSEPPE; LO: "A fragment-like approach to PYCR1 inhibition", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 29, no. 18, 25 July 2019 (2019-07-25), Amsterdam NL , pages 2626 - 2631, XP085779561, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2019.07.047
DATABASE Registry 16 May 2019 (2019-05-16), ANONYMOUS : " 2-Propynamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-(2-methoxyphenyl)- (CA INDEX NAME)", XP093112103, retrieved from stnEXT Database accession no. 2308935-75-1
DATABASE Registry 23 February 2006 (2006-02-23), ANONYMOUS : "Benzenesulfonamide, 4-[2-[(3-phenyl-2-propyn-1-yl)amino]ethyl]- (CA INDEX NAME)", XP093112106, retrieved from STNext Database accession no. 875002-40-7