Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CD8+ MEMORY T CELL-MEDIATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/130467
Kind Code:
A2
Abstract:
The present invention relates to a composition for prevention, alleviation, or treatment of CD8+memory T cell-mediated disease. On the basis of the fact that CD69+ CD103- CD8+ memory T cells among CD8+ memory T cells residing in the liver form a tissue-resident subpopulation, the composition according to the present invention inhibits the expression level or activity of HIF-2α, which is specifically present at a high expression level only in CD69+ CD103- CD8+ memory T cells, thereby inducing the death of CD69+ CD103- CD8+ memory T cells or effectively suppressing the function thereof. Furthermore, exhibiting such effects, the composition can be applied to the prevention, alleviation, or treatment of CD8+ memory T cell-mediated disease.
Inventors:
SHIN EUI CHEOL (KR)
HAN JI WON (KR)
KIM JONG HOON (KR)
HAN JI WON (KR)
KIM JONG HOON (KR)
Application Number:
PCT/KR2019/017416
Publication Date:
June 25, 2020
Filing Date:
December 10, 2019
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K31/7088
Attorney, Agent or Firm:
LEE, Jae Young (KR)
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