Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF HEART FAILURE
Document Type and Number:
WIPO Patent Application WO/2019/066548
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical composition for prevention and treatment of heart failure. Specifically, the present invention relates to a gene construct comprising a polynucleotide coding for SERCA2a protein or a fragment thereof and a polynucleotide coding for CCN5 protein or a fragment thereof, and a pharmaceutical composition comprising the same construct as an effective ingredient for preventing or treating heart failure. A pharmaceutical composition for prevention and treatment of heart failure according to the present invention is used in a method for co-expression of SERCA2a protein and CCN5 protein. Designed to exert a synergistic therapeutic effect through SERCA2a protein's function of preventing the loss of cardiomyocytes and increasing the activity of cardiomyocytes and CCN5 protein's function of suppressing the fibrosis of heart cells and tissues, the pharmaceutical composition can be useful for preventing or treating heart failure, which is a complex disorder induced by various etiological factors.
Inventors:
JEONG DONGTAK (US)
KWAK TAE HWAN (KR)
PARK WOO JIN (KR)
KWAK TAE HWAN (KR)
PARK WOO JIN (KR)
Application Number:
PCT/KR2018/011521
Publication Date:
June 06, 2019
Filing Date:
September 28, 2018
Export Citation:
Assignee:
BETHPHAGEN INC (KR)
International Classes:
C12N15/86; A61K38/00; A61K48/00; C07K14/47; C12N9/14
Domestic Patent References:
| WO2016055437A1 | 2016-04-14 |
Foreign References:
| KR20170056460A | 2017-05-23 | |||
| US20170014494A1 | 2017-01-19 | |||
| KR20110105957A | 2011-09-28 |
Other References:
DATABASE GenBank 19 March 2015 (2015-03-19), "WISP2, partial [synthetic construct", XP55617240, Database accession no. AIC55480.1
DATABASE GenBank 14 December 2016 (2016-12-14), "Homo sapiens connective tissue growth factor related protein WISP-2 (WISP2) mRNA, complete cds", XP55617245, Database accession no. AF100780.2
DATABASE GenBank 4 May 2016 (2016-05-04), "Cloning vector PV512 complete sequence", XP55617249, Database accession no. KU665997.1
DATABASE GenBank 14 December 2016 (2016-12-14), "Homo sapiens connective tissue growth factor related protein WISP-2 (WISP2) mRNA, complete cds", XP55617245, Database accession no. AF100780.2
DATABASE GenBank 4 May 2016 (2016-05-04), "Cloning vector PV512 complete sequence", XP55617249, Database accession no. KU665997.1
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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