Title:
PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF PAIN AND SCREENING METHOD FOR PAIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/114167
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition for the prevention and/or treatment of pain, which is capable of effectively relieving pain. The pharmaceutical composition for the prevention and/or treatment of pain is characterized by containing, as an effective component thereof, a siRNA, shRNA or antisense oligonucleotide of the SNX25 gene which inhibits the expression of SNX25. The pain is neuropathic or nociceptive pain. The pharmaceutical composition for the prevention and/or treatment of pain is also characterized by containing, as an effective component thereof, an antibody that specifically binds to SNX25.
Inventors:
TANAKA TATSUHIDE (JP)
WANAKA AKIO (JP)
WANAKA AKIO (JP)
Application Number:
PCT/JP2021/043557
Publication Date:
June 02, 2022
Filing Date:
November 29, 2021
Export Citation:
Assignee:
PUBLIC UNIV CORPORATION NARA MEDICAL UNIV (JP)
International Classes:
A61K31/713; A61K39/395; A61P25/04; A61P29/02; C07K16/28; C12N15/113; C12N15/13; C12P21/08; C12Q1/02; C12Q1/6813
Other References:
ANONYMOUS: "SNX25 Polyclonal antibody SDS (13294-1-AP)", pages 1 - 2, XP009538119, Retrieved from the Internet [retrieved on 20220809]
ANONYMOUS: "SNX25 Polyclonal Antibody SDS (bs-4070R)", 1 January 2021 (2021-01-01), USA, XP009537031, Retrieved from the Internet
XINBAO HAO; YINYIN WANG; FANGLI REN; SHANSHAN ZHU; YONGMING REN; BAOQING JIA; YI-PING LI; YUGUANG SHI; ZHIJIE CHANG;: "SNX25 regulates TGF- signaling by enhancing the receptor degradation", CELLULAR SIGNALLING, vol. 23, no. 5, 19 January 2011 (2011-01-19), GB , pages 935 - 946, XP028152980, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2011.01.022
TAKEMURA SHOKO; ISONISHI AYAMI; TANAKA TATSUHIDE; OKUDA HIROAKI; TATSUMI KOUKO; YAMANO MARIKO; WANAKA AKIO: "Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking", BRAIN STRUCTURE AND FUNCTION, vol. 225, no. 9, 1 January 2020 (2020-01-01), Berlin/Heidelberg , pages 2615 - 2642, XP037297623, ISSN: 1863-2653, DOI: 10.1007/s00429-020-02144-0
BLANEY DAVIDSON E.N., VAN CAAM A.P.M., VITTERS E.L., BENNINK M.B., THIJSSEN E., VAN DEN BERG W.B., KOENDERS M.I., VAN LENT P.L.E.M: "TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?", OSTEOARTHRITIS AND CARTILAGE, vol. 23, no. 3, 1 March 2015 (2015-03-01), AMSTERDAM, NL, pages 478 - 486, XP055935533, ISSN: 1063-4584, DOI: 10.1016/j.joca.2014.12.005
CAO TUOXIN, MATYAS JESSICA J., RENN CYNTHIA L., FADEN ALAN I., DORSEY SUSAN G., WU JUNFANG: "Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain", CELLS, vol. 9, no. 5, 11 May 2020 (2020-05-11), pages 1 - 17, XP055935534, DOI: 10.3390/cells9051194
ANONYMOUS: "SNX25 Polyclonal Antibody SDS (bs-4070R)", 1 January 2021 (2021-01-01), USA, XP009537031, Retrieved from the Internet
XINBAO HAO; YINYIN WANG; FANGLI REN; SHANSHAN ZHU; YONGMING REN; BAOQING JIA; YI-PING LI; YUGUANG SHI; ZHIJIE CHANG;: "SNX25 regulates TGF- signaling by enhancing the receptor degradation", CELLULAR SIGNALLING, vol. 23, no. 5, 19 January 2011 (2011-01-19), GB , pages 935 - 946, XP028152980, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2011.01.022
TAKEMURA SHOKO; ISONISHI AYAMI; TANAKA TATSUHIDE; OKUDA HIROAKI; TATSUMI KOUKO; YAMANO MARIKO; WANAKA AKIO: "Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking", BRAIN STRUCTURE AND FUNCTION, vol. 225, no. 9, 1 January 2020 (2020-01-01), Berlin/Heidelberg , pages 2615 - 2642, XP037297623, ISSN: 1863-2653, DOI: 10.1007/s00429-020-02144-0
BLANEY DAVIDSON E.N., VAN CAAM A.P.M., VITTERS E.L., BENNINK M.B., THIJSSEN E., VAN DEN BERG W.B., KOENDERS M.I., VAN LENT P.L.E.M: "TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?", OSTEOARTHRITIS AND CARTILAGE, vol. 23, no. 3, 1 March 2015 (2015-03-01), AMSTERDAM, NL, pages 478 - 486, XP055935533, ISSN: 1063-4584, DOI: 10.1016/j.joca.2014.12.005
CAO TUOXIN, MATYAS JESSICA J., RENN CYNTHIA L., FADEN ALAN I., DORSEY SUSAN G., WU JUNFANG: "Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain", CELLS, vol. 9, no. 5, 11 May 2020 (2020-05-11), pages 1 - 17, XP055935534, DOI: 10.3390/cells9051194
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
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