Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF TINEA
Document Type and Number:
WIPO Patent Application WO/2022/035031
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising: efinaconazole or a pharmaceutically acceptable salt thereof; and octenidine or a pharmaceutically acceptable salt thereof as active ingredients for preventing or treating Tinea unguium, Tinea corporis, and green nail syndrome. The composition of the present invention exhibits a wide spectrum of sterilizing effects including antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Aspergillus niger, Candida albicans, Epidermophyton floccosum, and Microsporum canis and antibacterial activity against Pseudomonas aeruginosa, which is a bacterium causative of green nail syndrome, and has improved drug permeability into the skin and the nail and as such, can be used as a therapeutic agent for Tinea unguium, Tinea corporis, and green nail syndrome. In addition, the composition does not change in physical property even when stored at 65℃ for 5 weeks or longer, thus guaranteeing the stability thereof.
Inventors:
CHANG BYEUNG MO (KR)
Application Number:
PCT/KR2021/006785
Publication Date:
February 17, 2022
Filing Date:
June 01, 2021
Export Citation:
Assignee:
BL&H CO LTD (KR)
International Classes:
A61K31/454; A61K9/00; A61K31/444; A61P31/10
Domestic Patent References:
| WO2015091692A1 | 2015-06-25 | |||
| WO2018110693A1 | 2018-06-21 |
Foreign References:
| KR20200081432A | 2020-07-07 | |||
| CN111437276A | 2020-07-24 | |||
| KR20160087898A | 2016-07-22 | |||
| JP2011507978A | 2011-03-10 | |||
| KR102217617B1 | 2021-02-19 | |||
| KR102181155B1 | 2020-11-20 | |||
| KR20200140681A | 2020-12-16 | |||
| KR20160068812A | 2016-06-15 | |||
| KR20180046644A | 2018-05-09 |
Other References:
ELEWSKI, B. E. ET AL.: "Efinaconazole 10% solution in the treatment of toenail onychomycosis: Two phase III multicenter, randomized, double-blind studies", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, vol. 68, no. 4, 2013, pages 600 - 608, XP055363595, DOI: 10.1016/j.jaad.2012.10.013
KARPINSKI, T. M.: "Efficacy of octenidine against Pseudomonas aeruginosastrains", EUROPEAN JOURNAL OF BIOLOGICAL RESEARCH, vol. 9, no. 3, 2019, pages 135 - 140, XP055871471, DOI: 10.5281/zenodo.3339499
BYUNG HO OHKYU JOONG AHAN: "Drug Therapy of Dermatophytosis", J KOREAN MED ASSOC., vol. 52, no. 11, 2009, pages 1109 - 1114
UWE WOLLINAHOLGER HAENSSLE, DTSCH ARZTEBL INT, vol. 113, no. 29-30, 2016, pages 509 - 518
YANG WON LEE: "Treatment of onychomycosis", J KOREAN MED ASSOC, vol. 62, no. 7, July 2019 (2019-07-01), pages 385 - 391
SHITAL AMIN, POOJARY: "Topical Antifungals; A Review and their Role Management of Dermatophytoses", CLINICAL DERMATOLOGY REVIEW, vol. 1, 2017, pages s24 - s29
See also references of EP 3981402A4
KARPINSKI, T. M.: "Efficacy of octenidine against Pseudomonas aeruginosastrains", EUROPEAN JOURNAL OF BIOLOGICAL RESEARCH, vol. 9, no. 3, 2019, pages 135 - 140, XP055871471, DOI: 10.5281/zenodo.3339499
BYUNG HO OHKYU JOONG AHAN: "Drug Therapy of Dermatophytosis", J KOREAN MED ASSOC., vol. 52, no. 11, 2009, pages 1109 - 1114
UWE WOLLINAHOLGER HAENSSLE, DTSCH ARZTEBL INT, vol. 113, no. 29-30, 2016, pages 509 - 518
YANG WON LEE: "Treatment of onychomycosis", J KOREAN MED ASSOC, vol. 62, no. 7, July 2019 (2019-07-01), pages 385 - 391
SHITAL AMIN, POOJARY: "Topical Antifungals; A Review and their Role Management of Dermatophytoses", CLINICAL DERMATOLOGY REVIEW, vol. 1, 2017, pages s24 - s29
See also references of EP 3981402A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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