Title:
PHARMACEUTICAL COMPOSITION FOR SUPPRESSING FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2020/241778
Kind Code:
A1
Abstract:
Provided is a substance that treats or prevents inflammation and/or fibrotic conditions of the heart, kidney, or lung caused by chronic kidney disease. The present invention relates to a pharmaceutical composition for treating or preventing inflammatory and/or fibrotic conditions that contains homoharringtonine or the like as an active ingredient.
Inventors:
MATSUNAGA NAOYA (JP)
OHDO SHIGEHIRO (JP)
OHDO SHIGEHIRO (JP)
Application Number:
PCT/JP2020/021192
Publication Date:
December 03, 2020
Filing Date:
May 28, 2020
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61P9/00; A61K9/127; A61K31/55; A61P11/00; A61P13/12; A61P29/00; A61P43/00; C12N15/12; C12Q1/02; C12Q1/6851; C12Q1/686; G01N33/15; G01N33/50; G01N33/68
Foreign References:
| JP2016521540A | 2016-07-25 |
Other References:
LI, X. ET AL.: "Homoharringtonine prevents surgery- induced epidural fibrosis through endoplasmic reticulum stress signaling pathway", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 815, 2017, pages 437 - 445, XP085245809, DOI: 10.1016/j.ejphar.2017.09.027
HONGBO LI, ZHENKAI WANG, JIE ZHANG, YOULEI WANG, CHEN YU, JINJIN ZHANG, XIAODONG SONG & CHANGJUN LV: "Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 18, 234, 2018, pages 1 - 13, XP055769447
SENTA HUTTER, WOUTER T VAN HAAFTEN, ANOUK HÜNERWADEL, KATHARINA BAEBLER, NEEL HERFARTH, TINA RASELLI, CÉLINE MAMIE, BENJAMIN MISSE: "Intestinal activation of pH- sensing receptor OGR1 [GPR68] contributes to fibrogenesis", JOURNAL OF CROHN'S & COLITIS, vol. 12, no. 11, 2018, pages 1348 - 1358, XP055769450
CHERYL DE VALLIÈRE, MSC,* YU WANG, MSC,*,† JYRKI J. ELORANTA, PHD,‡ SOLANGE VIDAL, MSC,§ IEUAN CLAY, PHD,§ MARIANNE R. SPALINGER, : "G protein-coupled pH- sensing receptor OGR1 is a regulator of intestinal inflammation", INFLAMMATORY BOWEL DISEASES, vol. 21, no. 6, 2015, pages 1269 - 1281, XP055769451
NAGASAKA, AKIOMI ET AL.: "Physiological importance of pH-sensing GPCRs in macrophages", AGRICULTURAL BIOTECHNOLOGY, vol. 2, no. 11, 2018, pages 1109 - 1113
CHERYL DE VALLIÈRE, JESUS COSIN-ROGER, SIMONA SIMMEN, KIRSTIN ATROTT, HASSAN MELHEM, JONAS ZEITZ, MEHDI MADANCHI, IRINA TCYMBARE: "Hypoxia positively regulates the expression of pH-sensing G-protein- coupled receptor OGR1 (GPR68)", CELL . MOL. GASTROENTEROL. HEPATOL., vol. 2, 2016, pages 796 - 810, XP055769453
HONGBO LI, ZHENKAI WANG, JIE ZHANG, YOULEI WANG, CHEN YU, JINJIN ZHANG, XIAODONG SONG & CHANGJUN LV: "Feifukang ameliorates pulmonary fibrosis by inhibiting JAK-STAT signaling pathway", BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 18, 234, 2018, pages 1 - 13, XP055769447
SENTA HUTTER, WOUTER T VAN HAAFTEN, ANOUK HÜNERWADEL, KATHARINA BAEBLER, NEEL HERFARTH, TINA RASELLI, CÉLINE MAMIE, BENJAMIN MISSE: "Intestinal activation of pH- sensing receptor OGR1 [GPR68] contributes to fibrogenesis", JOURNAL OF CROHN'S & COLITIS, vol. 12, no. 11, 2018, pages 1348 - 1358, XP055769450
CHERYL DE VALLIÈRE, MSC,* YU WANG, MSC,*,† JYRKI J. ELORANTA, PHD,‡ SOLANGE VIDAL, MSC,§ IEUAN CLAY, PHD,§ MARIANNE R. SPALINGER, : "G protein-coupled pH- sensing receptor OGR1 is a regulator of intestinal inflammation", INFLAMMATORY BOWEL DISEASES, vol. 21, no. 6, 2015, pages 1269 - 1281, XP055769451
NAGASAKA, AKIOMI ET AL.: "Physiological importance of pH-sensing GPCRs in macrophages", AGRICULTURAL BIOTECHNOLOGY, vol. 2, no. 11, 2018, pages 1109 - 1113
CHERYL DE VALLIÈRE, JESUS COSIN-ROGER, SIMONA SIMMEN, KIRSTIN ATROTT, HASSAN MELHEM, JONAS ZEITZ, MEHDI MADANCHI, IRINA TCYMBARE: "Hypoxia positively regulates the expression of pH-sensing G-protein- coupled receptor OGR1 (GPR68)", CELL . MOL. GASTROENTEROL. HEPATOL., vol. 2, 2016, pages 796 - 810, XP055769453
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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