Title:
PHARMACEUTICAL COMPOSITION FOR THICKENING ENDOMETRIUM
Document Type and Number:
WIPO Patent Application WO/2022/124494
Kind Code:
A1
Abstract:
A pharmaceutical composition according to the present invention comprises a first liquid containing PEG-VS and a second liquid containing a crosslinker inclusive of an amino acid sequence cleaved by a proteinase, wherein the first liquid or the second liquid contains a growth factor.
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Inventors:
LEE SEUNG-TAE (KR)
YUN JUNG-IM (KR)
KIM KEUN-CHEON (KR)
PARK HYE-JIN (KR)
YUN JUNG-IM (KR)
KIM KEUN-CHEON (KR)
PARK HYE-JIN (KR)
Application Number:
PCT/KR2021/005903
Publication Date:
June 16, 2022
Filing Date:
May 11, 2021
Export Citation:
Assignee:
KUSTOGEN INC (KR)
KANGWON NATIONAL UNIV INDUSTRY COOPERATION FOUNDATION (KR)
KANGWON NATIONAL UNIV INDUSTRY COOPERATION FOUNDATION (KR)
International Classes:
A61K9/06; A61K9/00; A61K38/18; A61K38/19; A61K47/10; A61K47/20; A61K47/42; A61P15/02
Foreign References:
| KR20050052548A | 2005-06-02 |
Other References:
PATTERSON, J. ; HUBBELL, J.A.: "Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 31, no. 30, 1 October 2010 (2010-10-01), AMSTERDAM, NL , pages 7836 - 7845, XP027219014, ISSN: 0142-9612
GARCÍA ANDRÉS J.: "PEG–Maleimide Hydrogels for Protein and Cell Delivery in Regenerative Medicine", ANNALS OF BIOMEDICAL ENGINEERING, SPRINGER US, NEW YORK, vol. 42, no. 2, 1 February 2014 (2014-02-01), New York , pages 312 - 322, XP055896674, ISSN: 0090-6964, DOI: 10.1007/s10439-013-0870-y
LUTOLF M P ET AL: "Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 5413 - 5418, XP002321593, ISSN: 0027-8424, DOI: 10.1073/pnas.0737381100
BAKAIC EMILIA, SMEETS NIELS M B, HOARE TODD: "INJECTABLE HYDROGELS BASED ON POLY(ETHYLENE GLYCOL) AND DERIVATIVES AS FUNCTIONAL BIOMATERIALS ", RSC ADVANCES, vol. 5, 1 January 2015 (2015-01-01), pages 35469 - 35486, XP055942000
GARCÍA ANDRÉS J.: "PEG–Maleimide Hydrogels for Protein and Cell Delivery in Regenerative Medicine", ANNALS OF BIOMEDICAL ENGINEERING, SPRINGER US, NEW YORK, vol. 42, no. 2, 1 February 2014 (2014-02-01), New York , pages 312 - 322, XP055896674, ISSN: 0090-6964, DOI: 10.1007/s10439-013-0870-y
LUTOLF M P ET AL: "Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 5413 - 5418, XP002321593, ISSN: 0027-8424, DOI: 10.1073/pnas.0737381100
BAKAIC EMILIA, SMEETS NIELS M B, HOARE TODD: "INJECTABLE HYDROGELS BASED ON POLY(ETHYLENE GLYCOL) AND DERIVATIVES AS FUNCTIONAL BIOMATERIALS ", RSC ADVANCES, vol. 5, 1 January 2015 (2015-01-01), pages 35469 - 35486, XP055942000
Attorney, Agent or Firm:
CHOI, Jung-moon (KR)
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