Title:
A PHARMACEUTICAL COMPOSITION FOR TREATING ACIDS AND ITS PREPARATION
Document Type and Number:
WIPO Patent Application WO/2002/026259
Kind Code:
A1
Abstract:
The invention discloses a pharmaceutical composition useful for treating ACIDS and its preparation, the present pharmaceutical composition useful for treating ACIDS, substantially comprises at least one monoclonal antibody, said antibody against antigen which is neutralizing epitope, GPGRAFY, based on envelope protein of human immunodeficiency virus (HIV), ant its variants, said variant is GPGQTFY or GPGQAWY. The method for preparing the present pharmaceutical composition comprises: (1) synthesizing at least one peptide comprising neutralizing epitope, GPGRAFY, based on envelope protein of human immunodeficiency virus (HIV), and/or its variants; (2) conjugating said peptide to carrier protein or carrier polypeptide respectively; (3) immunising animal with said conjugates; (4) preparing hybridoma; (5) combining said three neutralizing antibody formulating the present pharmaceutical composition.
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Inventors:
CHEN YINGHUA (CN)
TIAN HAIJUN (CN)
XIAO YI (CN)
TIAN HAIJUN (CN)
XIAO YI (CN)
Application Number:
PCT/CN2001/001191
Publication Date:
April 04, 2002
Filing Date:
July 20, 2001
Export Citation:
Assignee:
UNIV TSINGHUA (CN)
CHINATEX INDUSTRY DEV CORP (CN)
CHEN YINGHUA (CN)
TIAN HAIJUN (CN)
XIAO YI (CN)
CHINATEX INDUSTRY DEV CORP (CN)
CHEN YINGHUA (CN)
TIAN HAIJUN (CN)
XIAO YI (CN)
International Classes:
A61P31/18; C07K14/16; C07K16/10; A61K38/00; (IPC1-7): A61K39/42; A61P31/18; C07K14/155; C07K16/10
Domestic Patent References:
| WO1993004090A1 | 1993-03-04 | |||
| WO1998015658A1 | 1998-04-16 |
Foreign References:
| US5911989A | 1999-06-15 | |||
| US5618922A | 1997-04-08 | |||
| US5266478A | 1993-11-30 | |||
| GB2223226A | 1990-04-04 |
Attorney, Agent or Firm:
JEEKAI & PARTNERS (Jinyu Tower A129 West Street Xuan Wu Men
Xicheng District Beijing 1, CN)
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