PHARMACEUTICAL COMPOSITION FOR TREATING ANXIETY DISORDER, CONTAINING N-ACETYL-L-CYSTEINE OR DERIVATIVE THEREOF

Title:

PHARMACEUTICAL COMPOSITION FOR TREATING ANXIETY DISORDER, CONTAINING N-ACETYL-L-CYSTEINE OR DERIVATIVE THEREOF

Document Type and Number:

WIPO Patent Application WO/2012/033235

Kind Code:

A1

Abstract:

The present invention relates to a composition for treating anxiety disorder, and more specifically, to a pharmaceutical composition for treating anxiety disorder such as posttraumatic stress disorder or phobia, containing N-acetyl-L-cysteine or a derivative thereof. In particular, according to the present invention, when N-acetyl-L-cysteine is administered during or after exposure therapy with respect to posttraumatic stress disorder and phobia, it is possible to block the relapse of fear memories for a long time.

Inventors:

CHOI SUK WOO (KR)
LEE SUK WON (KR)
KIM JEONG YEON (KR)
SONG BEOM JONG (KR)
HONG IN GIE (KR)
PARK SUNG MO (KR)
KIM JI HYE (KR)
LEE JUN UK (KR)
AN BO BAE (KR)

Application Number:

PCT/KR2010/006035

Publication Date:

March 15, 2012

Filing Date:

September 06, 2010

Export Citation:

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Assignee:

SUN R & DB FOUNDATION (KR)
CHOI SUK WOO (KR)
LEE SUK WON (KR)
KIM JEONG YEON (KR)
SONG BEOM JONG (KR)
HONG IN GIE (KR)
PARK SUNG MO (KR)
KIM JI HYE (KR)
LEE JUN UK (KR)
AN BO BAE (KR)

International Classes:

A61K31/195; A61K31/355; A61K31/51; A61K31/525; A61K33/00; A61P25/22

Foreign References:

KR20080028357A	2008-03-31
US20060257502A1	2006-11-16

Other References:

SANJAY J.M. ET AL.: "Recent Advances in the Neurobiology of Anxiety Disorders: Implications for Novel Therapeutics", AM.J.MED.GENET. PART C, vol. 148C, 2008, pages 89 - 98, XP055082259
See also references of EP 2614821A4
MOUSSAWI ET AL., NAT.NEUROSCI., no. 2, 2009, pages 182 - 9
SCHILLER ET AL., NATURE, vol. 463, no. 7277, 2010, pages 49 - 53
KINDT ET AL., NAT. NEUROSCI., vol. 12, no. 3, 2009, pages 256 - 8
RESSLER ET AL., ARCH. GEN. PSYCHIATRY, 2004, pages 1138 - 42
LEONID GRINBERG ET AL., FREE RADICAL BIOLOGY & MEDICINE., vol. 38, 2005, pages 136 - 145
UZMA I. ZAKAI ET AL., APPL. ORGANOMETAL. CHEM., vol. 24, 2010, pages 189 - 192
KIM ET AL., PNAS, vol. 104, 2007, pages 20955 - 960

Attorney, Agent or Firm:

KIM, SOON WOONG (KR)
김순웅 (KR)

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