Title:
PHARMACEUTICAL COMPOSITION FOR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2023/008570
Kind Code:
A1
Abstract:
Provided herein is a pharmaceutical composition for treating cancer, the pharmaceutical composition containing: a folic acid-modified hydroxyalkylated cyclodextrin selected from the group consisting of folic acid-modified hydroxypropylcyclodextrin, folic acid-modified hydroxybutylcyclodextrin, and folic acid-modified hydroxyethyl cyclodextrin; or a derivative thereof. Thus, a novel pharmaceutical composition for treating cancer and the like is provided.
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Inventors:
KIMURA SHINYA (JP)
KUBOTA YASUSHI (JP)
MOTOYAMA KEIICHI (JP)
HIGASHI TAISHI (JP)
ARIMA HIDETOSHI (JP)
KUBOTA YASUSHI (JP)
MOTOYAMA KEIICHI (JP)
HIGASHI TAISHI (JP)
ARIMA HIDETOSHI (JP)
Application Number:
PCT/JP2022/029345
Publication Date:
February 02, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
UNIV SAGA (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K31/7064; A61K9/08; A61K9/19; A61K45/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| WO2014087778A1 | 2014-06-12 | |||
| WO2014087778A1 | 2014-06-12 |
Foreign References:
| CN102512683A | 2012-06-27 | |||
| JP2016069520A | 2016-05-09 | |||
| JP2014001204A | 2014-01-09 | |||
| JP2014001204A | 2014-01-09 | |||
| JP2016069520A | 2016-05-09 | |||
| JP2021126032A | 2021-08-30 |
Other References:
YAN JUN, LI QING-FANG, WANG LI-SHENG, WANG HUA, XIAO FENG-JUN, YANG YUE-FENG, WU CHU-TSE: "Methyl-β-cyclodextrin induces programmed cell death in chronic myeloid leukemia cells and, combined with imatinib, produces a synergistic downregulation of ERK/SPK1 signaling", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 23, no. 1, 31 December 2011 (2011-12-31), US , pages 22 - 31, XP009542884, ISSN: 0959-4973, DOI: 10.1097/CAD.0b013e32834a099c
HOSHIKO TOSHIMI, KUBOTA YASUSHI, ONODERA RISAKO, HIGASHI TAISHI, YOKOO MASAKO, MOTOYAMA KEIICHI, KIMURA SHINYA: "Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death", CANCERS, vol. 13, no. 21, pages 5413, XP093028387, DOI: 10.3390/cancers13215413
YOKOO ET AL., PLOS ONE, vol. 10, no. 11, 2015, pages e0141946
OKAMATSU ET AL., BIOMACROMOLECULES, vol. 14, 2013, pages 4420 - 4428
NIEMANN-PICK, INT. J. MOL. SCI, vol. 22, 2021, pages 452, Retrieved from the Internet
HOSHIKO TOSHIMI, KUBOTA YASUSHI, ONODERA RISAKO, HIGASHI TAISHI, YOKOO MASAKO, MOTOYAMA KEIICHI, KIMURA SHINYA: "Folic Acid-Appended Hydroxypropyl-β-Cyclodextrin Exhibits Potent Antitumor Activity in Chronic Myeloid Leukemia Cells via Autophagic Cell Death", CANCERS, vol. 13, no. 21, pages 5413, XP093028387, DOI: 10.3390/cancers13215413
YOKOO ET AL., PLOS ONE, vol. 10, no. 11, 2015, pages e0141946
OKAMATSU ET AL., BIOMACROMOLECULES, vol. 14, 2013, pages 4420 - 4428
NIEMANN-PICK, INT. J. MOL. SCI, vol. 22, 2021, pages 452, Retrieved from the Internet
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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