Title:
PHARMACEUTICAL COMPOSITION FOR TREATING CEREBROVASCULAR DISEASES, CONTAINING STEM CELL-DERIVED EXOSOME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2015/088286
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating cerebrovascular diseases, containing a stem cell-derived exosome as an active ingredient. The stem cell-derived exosome according to the present invention has remarkable nerve cell protective effects such as the inhibition of ventricular enlargement in the intraventricular hemorrhage (IVH) animal model, the decrease in hydrocephalus, and the inhibition of nerve cell death and inflammatory cells, and thus can be useful for treating cerebrovascular diseases including IVH and the like.
Inventors:
CHANG YUN SIL (KR)
PARK WON SOON (KR)
SUNG DONG KYUNG (KR)
AHN SO YOON (KR)
PARK WON SOON (KR)
SUNG DONG KYUNG (KR)
AHN SO YOON (KR)
Application Number:
PCT/KR2014/012289
Publication Date:
June 18, 2015
Filing Date:
December 12, 2014
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
International Classes:
A61K35/44; A61K35/12; A61K35/28; A61P25/00
Domestic Patent References:
| WO2013150303A1 | 2013-10-10 |
Foreign References:
| US20130273011A1 | 2013-10-17 |
Other References:
XIN, H. ET AL.: "Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 33, no. 11, 21 August 2013 (2013-08-21), pages 1711 - 1715, XP055226654
MAHMOOD, A. ET AL.: "Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury", JOURNAL OF NEUROTRAUMA, vol. 21, no. 1, 2004, pages 33 - 39, XP055348832
TEIXEIRA, F. G. ET AL.: "Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 70, no. 20, 1 March 2013 (2013-03-01), pages 3871 - 3882, XP035325020
MAHMOOD, A. ET AL.: "Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury", JOURNAL OF NEUROTRAUMA, vol. 21, no. 1, 2004, pages 33 - 39, XP055348832
TEIXEIRA, F. G. ET AL.: "Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?", CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 70, no. 20, 1 March 2013 (2013-03-01), pages 3871 - 3882, XP035325020
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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