Title:
PHARMACEUTICAL COMPOSITION FOR TREATING DISEASES, DISORDERS, OR SYMPTOMS RELATED TO ABNORMALITY IN IMMUNE SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/112992
Kind Code:
A1
Abstract:
The present disclosure provides a safe immunity control method. Provided is a pharmaceutical composition that contains CTLA-4 or a nucleic acid encoding same, or a functional equivalent thereof, or a factor that induces at least one thereof, for the prevention or therapy of wounds, or of diseases, disorders, or symptoms associated with wounds.
Inventors:
OSAKI MOTONAO (JP)
SAKAGUCHI SHIMON (JP)
SAKAGUCHI SHIMON (JP)
Application Number:
PCT/JP2022/046254
Publication Date:
June 22, 2023
Filing Date:
December 15, 2022
Export Citation:
Assignee:
REGCELL CO LTD (JP)
International Classes:
A61K38/17; A61K45/00; A61K48/00; A61P17/02; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07K7/06; C07K14/705; C12N15/12; C12Q1/02
Domestic Patent References:
| WO2020178865A1 | 2020-09-10 |
Foreign References:
| JP2015515282A | 2015-05-28 | |||
| JP2016519109A | 2016-06-30 | |||
| JP2007501243A | 2007-01-25 | |||
| JP2009520503A | 2009-05-28 | |||
| JP2004517806A | 2004-06-17 | |||
| JP2004535364A | 2004-11-25 |
Other References:
MESQUITA KARINE CESTARO; DANTAS THINALI SOUSA; DE BARROS SILVA PAULO GOBERLâNIO; DE QUEIROZ RODRIGUES MARIA IMACULADA; ALVES : "Abatacept treatment impairs the cell migration and wound healing of oral ulcers in rats: Role of interleukin (IL)-1β, -6 and -10 and CD8/CD30 cells Influence of abatacept treatment on oral wound healing: Experimental model on rats", LIFE SCIENCE, PERGAMON PRESS, OXFORD, GB, vol. 243, 7 January 2020 (2020-01-07), GB , XP086027092, ISSN: 0024-3205, DOI: 10.1016/j.lfs.2019.117243
OSAKI, M. et al. Soluble form of CTLA-4 produced by regulatory T Cells facilitates M2 macrophage differentiation in auto-inflammatory condition. 日本免疫学会総会・学術集会記録, 2016, vol. 45, no. proceedings, page 193, 3-G-W35-5-O/P, non-official translation (Japanese Society for Immunology General Meeting/Academic Meeting Record.)
KIM SANG YONG, NAIR MEERA G: "Macrophages in wound healing: activation and plasticity", IMMUNOLOGY AND CELL BIOLOGY, CARLTON, AU, vol. 97, no. 3, 1 March 2019 (2019-03-01), AU , pages 258 - 267, XP093070994, ISSN: 0818-9641, DOI: 10.1111/imcb.12236
GE, L. ; XIONG, F. ; ZHANG, W. ; KONG, Y. ; WU, J. ; WEI, H.: "In Vitro Ad5F35-Mediated CTLA4-Ig Gene Transfer Prolongs Pig Skin Xenotransplant Survival", TRANSPLANTATION PROCEEDINGS, ELSEVIER INC., ORLANDO, FL; US, vol. 42, no. 9, 1 November 2010 (2010-11-01), ORLANDO, FL; US , pages 3763 - 3766, XP027507856, ISSN: 0041-1345, DOI: 10.1016/j.transproceed.2010.09.011
CUTOLO MAURIZIO, SOLDANO STEFANO, GOTELLI EMANUELE, MONTAGNA PAOLA, CAMPITIELLO ROSANNA, PAOLINO SABRINA, PIZZORNI CARMEN, SULLI A: "CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients", ARTHRITIS RESEARCH & THERAPY, vol. 23, no. 1, 1 December 2021 (2021-12-01), pages 306, XP093070996, DOI: 10.1186/s13075-021-02691-9
CUTOLO M., TARDITO S., GOTELLI E., MONTAGNA P., CAMPITIELLO R., PAOLINO S., PIZZORNI C., SULLI A., SMITH V., SOLDANO S.: "AB0092 CTLA4-Ig PROMOTES THE M1-M2 SHIFT IN CULTURED MACROPHAGES OF RHEUMATOID ARTHRITIS PATIENTS WITH ACTIVE DISEASE: IN VITRO STUDY", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, GB, vol. 81, no. Suppl 1, 1 June 2022 (2022-06-01), GB , pages 1177.2 - 1177, XP093070997, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2022-eular.4515
OSAKI, M. et al. Soluble form of CTLA-4 produced by regulatory T Cells facilitates M2 macrophage differentiation in auto-inflammatory condition. 日本免疫学会総会・学術集会記録, 2016, vol. 45, no. proceedings, page 193, 3-G-W35-5-O/P, non-official translation (Japanese Society for Immunology General Meeting/Academic Meeting Record.)
KIM SANG YONG, NAIR MEERA G: "Macrophages in wound healing: activation and plasticity", IMMUNOLOGY AND CELL BIOLOGY, CARLTON, AU, vol. 97, no. 3, 1 March 2019 (2019-03-01), AU , pages 258 - 267, XP093070994, ISSN: 0818-9641, DOI: 10.1111/imcb.12236
GE, L. ; XIONG, F. ; ZHANG, W. ; KONG, Y. ; WU, J. ; WEI, H.: "In Vitro Ad5F35-Mediated CTLA4-Ig Gene Transfer Prolongs Pig Skin Xenotransplant Survival", TRANSPLANTATION PROCEEDINGS, ELSEVIER INC., ORLANDO, FL; US, vol. 42, no. 9, 1 November 2010 (2010-11-01), ORLANDO, FL; US , pages 3763 - 3766, XP027507856, ISSN: 0041-1345, DOI: 10.1016/j.transproceed.2010.09.011
CUTOLO MAURIZIO, SOLDANO STEFANO, GOTELLI EMANUELE, MONTAGNA PAOLA, CAMPITIELLO ROSANNA, PAOLINO SABRINA, PIZZORNI CARMEN, SULLI A: "CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients", ARTHRITIS RESEARCH & THERAPY, vol. 23, no. 1, 1 December 2021 (2021-12-01), pages 306, XP093070996, DOI: 10.1186/s13075-021-02691-9
CUTOLO M., TARDITO S., GOTELLI E., MONTAGNA P., CAMPITIELLO R., PAOLINO S., PIZZORNI C., SULLI A., SMITH V., SOLDANO S.: "AB0092 CTLA4-Ig PROMOTES THE M1-M2 SHIFT IN CULTURED MACROPHAGES OF RHEUMATOID ARTHRITIS PATIENTS WITH ACTIVE DISEASE: IN VITRO STUDY", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, GB, vol. 81, no. Suppl 1, 1 June 2022 (2022-06-01), GB , pages 1177.2 - 1177, XP093070997, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2022-eular.4515
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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