Title:
PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATION AND METABOLIC DISEASES, COMPRISING SUBCUTANEOUS ADIPOSE TISSUE STEM CELLS HAVING GABA SIGNALS ACTIVATED
Document Type and Number:
WIPO Patent Application WO/2020/222491
Kind Code:
A1
Abstract:
The composition comprising stem cells and a stem cell culture fluid which are responsive to GABA and derived from subcutaneous adipose tissue, according to the present application, inhibits the infiltration of adipose tissue macrophages (ATMs) into inguinal adipose tissue (IAT), thereby has an anti-diabetic effect of improving insulin resistance caused by obesity and an anti-inflammatory effect through the inhibition of macrophage infiltration, and thus can be effectively used in treating, or ameliorating the symptoms of, said diseases.
Inventors:
KIM JAE BUM (KR)
HWANG INJAE (KR)
CHOE SUNG SIK (KR)
NAHMGOONG HAHN (KR)
HWANG INJAE (KR)
CHOE SUNG SIK (KR)
NAHMGOONG HAHN (KR)
Application Number:
PCT/KR2020/005559
Publication Date:
November 05, 2020
Filing Date:
April 28, 2020
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K35/28; A61K38/17; A61P3/10; A61P29/00
Foreign References:
| JP2009528841A | 2009-08-13 | |||
| KR20120058865A | 2012-06-08 | |||
| KR20130050663A | 2013-05-16 | |||
| CN107007627A | 2017-08-04 |
Other References:
HWANG, INJAE: "Characterization of gut microbiota and adipose tissues in the regulation of obesity-induced insulin resistance", PH.D. THESIS, SEOUL NATIONAL UNIVERSITY GRADUATE SCHOOL, February 2018 (2018-02-01)
Attorney, Agent or Firm:
PARK, Weonmee (KR)
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