Title:
PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING ARTERIAL ANEURYSM, METHOD FOR ASSISTING DIAGNOSIS OF ARTERIAL ANEURYSM, AND METHOD FOR ASSESSING THERAPEUTIC DRUG FOR ARTERIAL ANEURYSM
Document Type and Number:
WIPO Patent Application WO/2023/127909
Kind Code:
A1
Abstract:
Provided is a therapeutic drug that is useful for treating arterial aneurysm. The pharmaceutical composition for treating and/or preventing arterial aneurysm comprises at least one of the following chemical agents i) to iii) as an active ingredient. i) A chemical agent targeting platelet-derived growth factor receptor β (PDGFR β); ii) a chemical agent that inhibits the function of desmoyokin (AHNAK); and iii) a chemical agent that inhibits signal transduction enhanced by a mutation in PDGFR β or AHNAK.
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Inventors:
NAKATOMI HIROFUMI (JP)
Application Number:
PCT/JP2022/048341
Publication Date:
July 06, 2023
Filing Date:
December 27, 2022
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K45/00; A61K31/404; A61K31/439; A61K31/4412; A61K31/4439; A61K31/47; A61K31/496; A61K31/506; A61K31/517; A61K31/53; A61K31/5377; A61K39/395; A61P9/00; C07D209/34; C07D213/81; C07D215/22; C07D239/94; C07D403/06; C07D513/04; C12Q1/6869; G01N33/53
Foreign References:
| JP2018504416A | 2018-02-15 |
Other References:
KARASOZEN YIGIT; OSBUN JOSHUA W.; PARADA CAROLINA ANGELICA; BUSALD TINA; TATMAN PHILIP; GONZALEZ-CUYAR LUIS F.; HALE CHRISTOPHER J: "Somatic PDGFRB Activating Variants in Fusiform Cerebral Aneurysms", THE AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS , CHICAGO , IL, US, vol. 104, no. 5, 1 January 1900 (1900-01-01), US , pages 968 - 976, XP085676539, ISSN: 0002-9297, DOI: 10.1016/j.ajhg.2019.03.014
TARA L. WENGER; RANDALL A. BLY; NATALIE WU; CATHERINE M. ALBERT; JULIE PARK; JOSEPH SHIEH; JIRAT CHENBHANICH; CARRIE L. HEIKE; MAR: "Activating variants in PDGFRB result in a spectrum of disorders responsive to imatinib monotherapy", AMERICAN JOURNAL OF MEDICAL GENETICS PART A, WILEY-LISS, INC., US, vol. 182, no. 7, 5 June 2020 (2020-06-05), US , pages 1576 - 1591, XP072317858, ISSN: 1552-4825, DOI: 10.1002/ajmg.a.61615
SAMUEL NARDIN, RADOVANOVIC IVAN: "Genetic basis of intracranial aneurysm formation and rupture: clinical implications in the postgenomic era", JOURNAL OF NEUROSURGERY, vol. 47, no. 1, 1 July 2019 (2019-07-01), pages E10, XP093075084, DOI: 10.3171/2019.4.10.3171/2019.4.FOCUS19204
LEE I H, SOHN M, LIM H J, YOON S, OH H, SHIN S, SHIN J H, OH S-H, KIM J, LEE D K, NOH D Y, BAE D S, SEONG J K, BAE Y S: "Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 33, no. 38, 1 September 2014 (2014-09-01), London , pages 4675 - 4684, XP093076209, ISSN: 0950-9232, DOI: 10.1038/onc.2014.69
TARA L. WENGER; RANDALL A. BLY; NATALIE WU; CATHERINE M. ALBERT; JULIE PARK; JOSEPH SHIEH; JIRAT CHENBHANICH; CARRIE L. HEIKE; MAR: "Activating variants in PDGFRB result in a spectrum of disorders responsive to imatinib monotherapy", AMERICAN JOURNAL OF MEDICAL GENETICS PART A, WILEY-LISS, INC., US, vol. 182, no. 7, 5 June 2020 (2020-06-05), US , pages 1576 - 1591, XP072317858, ISSN: 1552-4825, DOI: 10.1002/ajmg.a.61615
SAMUEL NARDIN, RADOVANOVIC IVAN: "Genetic basis of intracranial aneurysm formation and rupture: clinical implications in the postgenomic era", JOURNAL OF NEUROSURGERY, vol. 47, no. 1, 1 July 2019 (2019-07-01), pages E10, XP093075084, DOI: 10.3171/2019.4.10.3171/2019.4.FOCUS19204
LEE I H, SOHN M, LIM H J, YOON S, OH H, SHIN S, SHIN J H, OH S-H, KIM J, LEE D K, NOH D Y, BAE D S, SEONG J K, BAE Y S: "Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway", ONCOGENE, NATURE PUBLISHING GROUP UK, LONDON, vol. 33, no. 38, 1 September 2014 (2014-09-01), London , pages 4675 - 4684, XP093076209, ISSN: 0950-9232, DOI: 10.1038/onc.2014.69
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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