Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2023/224128
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating or preventing fibrosis, the pharmaceutical composition containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
Inventors:
MIYAJIMA ATSUSHI (JP)
KIDO TAKETOMO (JP)
OGURI HIROKI (JP)
TAKAHASHI NORIHITO (JP)
KANEKO NOBUTO (JP)
ISHIGA TAKEHIRO (JP)
ASANO YOSHIHIDE (JP)
IKAWA TETSUYA (JP)
MIYATO MITSURU (JP)
KIDO TAKETOMO (JP)
OGURI HIROKI (JP)
TAKAHASHI NORIHITO (JP)
KANEKO NOBUTO (JP)
ISHIGA TAKEHIRO (JP)
ASANO YOSHIHIDE (JP)
IKAWA TETSUYA (JP)
MIYATO MITSURU (JP)
Application Number:
PCT/JP2023/018828
Publication Date:
November 23, 2023
Filing Date:
May 19, 2023
Export Citation:
Assignee:
ISM CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61K31/436; A61K31/197; A61K45/00; A61P1/00; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P43/00; C07D491/22
Foreign References:
| JP2014051438A | 2014-03-20 |
Other References:
KOI HIKARI, TAKAHASHI NORIHITO, FUCHI YASUFUMI, UMENO TOMOHIRO, MURAMATSU YUKIKO, SEIMIYA HIROYUKI, KARASAWA SATORU, OGURI HIROKI: "A fully synthetic 6-aza-artemisinin bearing an amphiphilic chain generates aggregates and exhibits anti-cancer activities", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 18, no. 28, 22 July 2020 (2020-07-22), pages 5339 - 5343, XP093110210, ISSN: 1477-0520, DOI: 10.1039/D0OB00919A
DAI YI-FEI; ZHOU WEI-WEI; MENG JING; DU XIN-LIANG; SUI YUN-PENG; DAI LI; WANG PENG-QIAN; HUO HAI-RU; SUI FENG: "The pharmacological activities and mechanisms of artemisinin and its derivatives: a systematic review", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 26, no. 5, 18 February 2017 (2017-02-18), US , pages 867 - 880, XP036205750, ISSN: 1054-2523, DOI: 10.1007/s00044-016-1778-5
CHI LIU; XUE YANG; PING ZHU; MASAYUKI FUJINO; HIDENORI ITO; KIWAMU TAKAHASHI; MOTOWO NAKAJIMA; TOHRU TANAKA; JIUCUN WANG; JIAN ZHU: "Combination of 5‐aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft‐versus‐host disease", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 27, no. 10, 20 August 2018 (2018-08-20), COPENHAGEN; DK , pages 1104 - 1111, XP071778684, ISSN: 0906-6705, DOI: 10.1111/exd.13730
DAI YI-FEI; ZHOU WEI-WEI; MENG JING; DU XIN-LIANG; SUI YUN-PENG; DAI LI; WANG PENG-QIAN; HUO HAI-RU; SUI FENG: "The pharmacological activities and mechanisms of artemisinin and its derivatives: a systematic review", MEDICINAL CHEMISTRY RESEARCH, BIRKHAEUSER, BOSTON., US, vol. 26, no. 5, 18 February 2017 (2017-02-18), US , pages 867 - 880, XP036205750, ISSN: 1054-2523, DOI: 10.1007/s00044-016-1778-5
CHI LIU; XUE YANG; PING ZHU; MASAYUKI FUJINO; HIDENORI ITO; KIWAMU TAKAHASHI; MOTOWO NAKAJIMA; TOHRU TANAKA; JIUCUN WANG; JIAN ZHU: "Combination of 5‐aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft‐versus‐host disease", EXPERIMENTAL DERMATOLOGY, BLACKWELL MUNSGAARD, COPENHAGEN; DK, vol. 27, no. 10, 20 August 2018 (2018-08-20), COPENHAGEN; DK , pages 1104 - 1111, XP071778684, ISSN: 0906-6705, DOI: 10.1111/exd.13730
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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