Title:
PHARMACEUTICAL COMPOSITION FOR TREATING TUMORS AND USE
Document Type and Number:
WIPO Patent Application WO/2023/104151
Kind Code:
A1
Abstract:
The present invention relates to a combination of an FAK inhibitor, an anthracycline chemotherapeutic drug, and an immune checkpoint inhibitor to treat tumors. The present invention also relates to a combination of an FAK inhibitor and an anthracycline chemotherapeutic drug to treat tumors.
Inventors:
ZHANG BAOYUAN (CN)
LIU XUEBIN (CN)
WANG ZAIQI (CN)
LIU XUEBIN (CN)
WANG ZAIQI (CN)
Application Number:
PCT/CN2022/137545
Publication Date:
June 15, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
INXMED NANJING CO LTD (CN)
International Classes:
A61K31/506; A61K45/06; A61K31/704; A61K39/395; A61P35/02
Domestic Patent References:
| WO2021154929A1 | 2021-08-05 | |||
| WO2021195415A1 | 2021-09-30 |
Foreign References:
| CN114667144A | 2022-06-24 | |||
| CN115429883A | 2022-12-06 |
Other References:
RAVANDI FARHAD, ASSI RITA, DAVER NAVAL, BENTON CHRISTOPHER, KADIA TAPAN, THOMPSON PHILIP, BORTHAKUR GAUTAM, ALVARADO YESID, JABBOU: "Idarubicin, Cytarabine, and Nivolumab in Patients with Newly Diagnosed Acute Myeloid Leukaemia or High-Risk Myelodysplastic Syndrome: a Single-Arm, Phase 2 Study", LANCET HAEMATOL, vol. 6, no. 9, 30 September 2019 (2019-09-30), pages e480 - e488, XP009546193, ISSN: 2352-3026, DOI: 10.1016/S2352-3026(19)30114-0
CHENG ZHAOKANG, DIMICHELE LAURA A., ROJAS MAURICIO, VAZIRI CYRUS, MACK CHRISTOPHER P., TAYLOR JOAN M.: "Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY., ACADEMIC PRESS, GB, vol. 67, 1 February 2014 (2014-02-01), GB , pages 1 - 11, XP093071039, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2013.12.002
ZHANG BAOYUAN, ZHANG YAN, ZHANG JIANGWEI, LIU PING, JIAO BO, WANG ZAIQI, REN RUIBAO: "Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAKâYAP Signaling", ADVANCED SCIENCE, vol. 8, no. 16, 1 August 2021 (2021-08-01), pages 2100250, XP093036363, ISSN: 2198-3844, DOI: 10.1002/advs.202100250
CHENG ZHAOKANG, DIMICHELE LAURA A., ROJAS MAURICIO, VAZIRI CYRUS, MACK CHRISTOPHER P., TAYLOR JOAN M.: "Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY., ACADEMIC PRESS, GB, vol. 67, 1 February 2014 (2014-02-01), GB , pages 1 - 11, XP093071039, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2013.12.002
ZHANG BAOYUAN, ZHANG YAN, ZHANG JIANGWEI, LIU PING, JIAO BO, WANG ZAIQI, REN RUIBAO: "Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAKâYAP Signaling", ADVANCED SCIENCE, vol. 8, no. 16, 1 August 2021 (2021-08-01), pages 2100250, XP093036363, ISSN: 2198-3844, DOI: 10.1002/advs.202100250
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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