Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER AND ASTHMA
Document Type and Number:
WIPO Patent Application WO/2010/067882
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for treating cancer and asthma. Specifically disclosed is a pharmaceutical composition containing siRNA capable of cleaving mucin subtype 5AC mRNA by means of RNA interference or an antibody directed against mucin subtype 5AC as an active ingredient. The pharmaceutical composition can treat diseases associated with overexpression of MUC5AC efficiently. When the pharmaceutical composition contains the siRNA, the pharmaceutical composition can be used effectively for the treatment of cancer that is characterized by the expression of MUC5AC, particularly pancreatic cancer. The siRNA or the antibody can inhibit the expression or function of MUC5AC, thereby preventing or treating the symptoms of asthma effectively.
Inventors:
HOSHI HIROTAKA (JP)
UCHIDA MOTOYUKI (JP)
SAITO HIKARU (JP)
UCHIDA MOTOYUKI (JP)
SAITO HIKARU (JP)
Application Number:
PCT/JP2009/070812
Publication Date:
June 17, 2010
Filing Date:
December 14, 2009
Export Citation:
Assignee:
KUREHA CORP (JP)
HOSHI HIROTAKA (JP)
UCHIDA MOTOYUKI (JP)
SAITO HIKARU (JP)
HOSHI HIROTAKA (JP)
UCHIDA MOTOYUKI (JP)
SAITO HIKARU (JP)
International Classes:
C12N15/113; A61K38/00; A61P37/06; A61P43/00; C12N15/09
Foreign References:
| JP2006519004A | 2006-08-24 |
Other References:
IACOBUZIO-DONAHUE, C.A. ET AL.: "Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies", CANCER RES., vol. 63, 15 December 2003 (2003-12-15), pages 8614 - 8622
HIROKAZU ARAKAWA ET AL.: "Zensoku ni Okeru Bunpi to sono Seigyo", JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 21, no. 2, 1 June 2007 (2007-06-01), pages 180 - 186
ORDONEZ, C.L. ET AL.: "Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression", AM. J. RESPIR. CRIT. CARE MED., vol. 163, no. 2, February 2001 (2001-02-01), pages 517 - 523
DATABASE GENBANK [online] 15 June 2008 (2008-06-15), retrieved from http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi? 161019169:NCBI:23039180 accession no. EMBL Database accession no. NM_017511
INTERNATIONAL JOURNAL OF GASTROINTESTINAL CANCER, vol. 34, 2003, pages 9 - 18
INTERNATIONAL JOURNAL OF ONCOLOGY (GREECE, vol. 24, 2004, pages 107 - L13
"Zensoku ni Okeru Bunpi to sono Seigyo", THE JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 21, 2007, pages 180 - 186
BRUMMERLKAMP,T.R. ET AL., SCIENCE, vol. 297, 2002, pages 1352 - 1354
LEE NS. ET AL., NATURE BIOTECH., vol. 20, 2002, pages 500 - 505
MIYAGISHI M., TAIRA K., NATURE BIOTECH., vol. 20, 2002, pages 497 - 500
PAUL CP. ET AL., NATURE BIOTECH., vol. 20, 2002, pages 505 - 508
BRUMMELKAMP TR ET AL., SCIENCE, vol. 296, 2002, pages 550 - 553
OSHIMA K. ET AL., CANCER RESEARCH, vol. 63, no. 15, 2003, pages 6809 - 6814
TERRETT, N. K. ET AL., TETRAHEDRON, vol. 51, 1995, pages 8135 - 8137
FELICI, F. ET AL., J. MOL. BIOL., vol. 222, 1991, pages 301 - 310
See also references of EP 2377934A4
HIROKAZU ARAKAWA ET AL.: "Zensoku ni Okeru Bunpi to sono Seigyo", JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 21, no. 2, 1 June 2007 (2007-06-01), pages 180 - 186
ORDONEZ, C.L. ET AL.: "Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression", AM. J. RESPIR. CRIT. CARE MED., vol. 163, no. 2, February 2001 (2001-02-01), pages 517 - 523
DATABASE GENBANK [online] 15 June 2008 (2008-06-15), retrieved from http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi? 161019169:NCBI:23039180 accession no. EMBL Database accession no. NM_017511
INTERNATIONAL JOURNAL OF GASTROINTESTINAL CANCER, vol. 34, 2003, pages 9 - 18
INTERNATIONAL JOURNAL OF ONCOLOGY (GREECE, vol. 24, 2004, pages 107 - L13
"Zensoku ni Okeru Bunpi to sono Seigyo", THE JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 21, 2007, pages 180 - 186
BRUMMERLKAMP,T.R. ET AL., SCIENCE, vol. 297, 2002, pages 1352 - 1354
LEE NS. ET AL., NATURE BIOTECH., vol. 20, 2002, pages 500 - 505
MIYAGISHI M., TAIRA K., NATURE BIOTECH., vol. 20, 2002, pages 497 - 500
PAUL CP. ET AL., NATURE BIOTECH., vol. 20, 2002, pages 505 - 508
BRUMMELKAMP TR ET AL., SCIENCE, vol. 296, 2002, pages 550 - 553
OSHIMA K. ET AL., CANCER RESEARCH, vol. 63, no. 15, 2003, pages 6809 - 6814
TERRETT, N. K. ET AL., TETRAHEDRON, vol. 51, 1995, pages 8135 - 8137
FELICI, F. ET AL., J. MOL. BIOL., vol. 222, 1991, pages 301 - 310
See also references of EP 2377934A4
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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