Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER, CONTAINING POLYPHENOL COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/142348
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating cancer, containing a polyphenol compound as an active ingredient. The pharmaceutical composition according to the present study is very effective for the treatment and prognosis-improvement of cancer stem cells or cancer tissues having a magnitude of cancer stem cells such as poorly differentiated cancer. Further, the polyphenol compound and a biguanide compound, and an anticancer agent were observed to remarkably increase inhibitory effects on the growth of cancerous cells when they were administered to cancerous cells in combination rather than individually, thus the composition is expected to find great applications in the cancer therapy field.
Inventors:
CHEONG JAE HO (KR)
KIM SOO YOUL (KR)
KIM SOO YOUL (KR)
Application Number:
PCT/KR2017/001783
Publication Date:
August 24, 2017
Filing Date:
February 17, 2017
Export Citation:
Assignee:
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
NAT CANCER CT (KR)
NAT CANCER CT (KR)
International Classes:
A61K31/11; A61K31/36; A61K31/37
Domestic Patent References:
| WO2015130109A1 | 2015-09-03 | |||
| WO2010056932A1 | 2010-05-20 |
Foreign References:
| US6114397A | 2000-09-05 | |||
| EP1474121B1 | 2010-07-21 | |||
| KR20110066035A | 2011-06-16 | |||
| US6114397A | 2000-09-05 |
Other References:
XIN, J. ET AL.: "ApoG2 as the Most Potent Gossypol Derivatives Inhibits Cell Growth and Induces Apoptosis on Gastric Cancer Cells", BIOMEDICINE & PHARMACOTHERAPY, vol. 67, 2013, pages 88 - 95, XP055549408
CELL DEATH DIS., vol. 6, 2 July 2015 (2015-07-02), pages el805
CELL DEATH DIS., vol. 6, 2 July 2015 (2015-07-02), pages el805
Attorney, Agent or Firm:
HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP (KR)
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