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Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF LUNG CANCER COMPRISING GLUCOCORTICOID-BASED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/078405
Kind Code:
A1
Abstract:
The present invention relates to a composition for treating or ameliorating lung cancer comprising a glucocorticoid-based compound, a glucocorticoid-based compound and an mTOR inhibitor, or a glucocorticoid-based compound and an AMPK inhibitor as an active ingredient. The glucocorticoid-based compounds inhibit the growth of cancer cells by suppressing NRF2 in KEAP1 mutant lung cancer or KEAP1 and LKB1 mutant lung cancer, and exhibit a more potent anticancer effect when used in combination with the mTOR inhibitor, and thus the compounds can be effectively used as anticancer agents for mutant lung cancer. In addition, one of the characteristics of tumor microenvironments, a low nutrient environment, induces activation of NRF2 and AMPK in KEAP1 and LKB1 normal lung cancer, and the glucocorticoid-based compounds exhibit a strong anticancer synergistic effect in a low nutritional state when treated in combination with an AMPK inhibitor in KEAP1 and LKB1 normal lung cancer, and thus the compounds can also be used as an anticancer agent for KEAP1 normal lung cancer.

Inventors:
JEON SANG-MIN (KR)
Application Number:
PCT/KR2016/012534
Publication Date:
May 11, 2017
Filing Date:
November 02, 2016
Export Citation:
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Assignee:
AJOU UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
A23L33/10; A61K31/573; A61K31/436
Other References:
HONMA, Y. ET AL.: "Vesnarinone and Glucocorticoids Cooperatively Induce G1 Arrest and have an Anti-tumour Effect on Human Non-small Cell Lung Carcinoma Celis Grown in Nude Mice", BRITISH JOURNAL OF CANCER, vol. 80, 1999, pages 96 - 103, XP055382368
GRIDELLI, C. ET AL.: "The Potential Role of mTOR Inhibitors in Non-small Cell Lung Cancer", THE ONCOLOGIST, vol. 13, 2008, pages 139 - 147, XP055037631
SOCINSKI, M. A. ET AL.: "The Current Status and Evolving Role of Sunitinib in Non-small Cell Lung Cancer", JOURNAL OF THORACIC ONCOLOGY, vol. 3, no. 6, 2008, pages S1 19 - S123, XP055382369
GREENBERG, A. K. ET AL.: "Glucocorticoids Inhibit Lung Cancer Cell Growth through Both the Extracellular Signal-related Kinase Pathway and Cell Cycle Regulators", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 27, 2002, pages 320 - 328, XP055382375
SKOULIDIS, F. ET AL.: "Co-occurring Genomic Alterations Define Major Subsets of KRAS-mutant Lung Adenocarcinoma with Distinct Biology, Immune Profiles, and Therapeutic Vulnerabilities", CANCER DISCOVERY, vol. 5, no. 8, August 2015 (2015-08-01), pages 860 - 877, XP055382376
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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