Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
Document Type and Number:
WIPO Patent Application WO/2015/020212
Kind Code:
A1
Abstract:
The objective of the present invention is to provide an antibody that targets CAPRIN-1 and that exhibits antitumor activity superior to that of conventional antibodies, and an application for said antibody as a therapeutic agent and/or preventative agent for cancer. The present invention provides an antibody that targets CAPRIN-1 polypeptides that are specifically expressed on the surface of cancer cells, and an application for the antibody as a therapeutic agent and/or preventative agent for cancer. Provided are an antibody that is immunologically reactive with CAPRIN1-protein and a fragment of said antibody, the antibody containing a heavy chain region including the complementarity determining regions of SEQ ID Nos. 1, 2 and 3, and a light chain region including the complementarity determining regions of SEQ ID Nos. 4, 5 and 6. Further provided is a pharmaceutical composition for the treatment and/or prevention of cancer and having the antibody or fragment as an active ingredient thereof.
Inventors:
OKANO FUMIYOSHI (JP)
SAITO TAKANORI (JP)
MINAMIDA YOSHITAKA (JP)
IDO TAKAYOSHI (JP)
SAITO TAKANORI (JP)
MINAMIDA YOSHITAKA (JP)
IDO TAKAYOSHI (JP)
Application Number:
PCT/JP2014/071094
Publication Date:
February 12, 2015
Filing Date:
August 08, 2014
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
C07K16/18; A61K39/395; A61K45/00; A61P35/00; A61P35/02; C07K16/46; C12N15/09; C12P21/08
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Other References:
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
"Protein Chemistry IV, Chemical Modification and Peptide Synthesis", 1981, TOKYO KAGAKU DOJIN CO., LTD., article "Seikagaku Jikken Koza 1"
SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
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CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
GROTH, S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
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GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER, G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
CARL, A.K. BORREBAECK; JAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ.; SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER, W.; FRITZ, HJ., METHODS ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA., PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTE OF HEALTH
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
G.-B. KIM ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 20, no. 9, 2007, pages 425 - 432
P.J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
P. SHEPHERD; C. DEAN.: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: principles and practice", 1993, ACADEMIC PRESS
HIDEO SAJI, YAKUGAKU ZASSHI, vol. 128, no. 3, August 2008 (2008-08-01), pages 323 - 332
See also references of EP 3031826A4
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
"Protein Chemistry IV, Chemical Modification and Peptide Synthesis", 1981, TOKYO KAGAKU DOJIN CO., LTD., article "Seikagaku Jikken Koza 1"
SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
GROTH, S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I.S., J.EXP.MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER, G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
CARL, A.K. BORREBAECK; JAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ.; SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER, W.; FRITZ, HJ., METHODS ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA., PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTE OF HEALTH
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
G.-B. KIM ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 20, no. 9, 2007, pages 425 - 432
P.J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
P. SHEPHERD; C. DEAN.: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: principles and practice", 1993, ACADEMIC PRESS
HIDEO SAJI, YAKUGAKU ZASSHI, vol. 128, no. 3, August 2008 (2008-08-01), pages 323 - 332
See also references of EP 3031826A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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