Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER
Document Type and Number:
WIPO Patent Application WO/2015/020212
Kind Code:
A1
Abstract:
 The objective of the present invention is to provide an antibody that targets CAPRIN-1 and that exhibits antitumor activity superior to that of conventional antibodies, and an application for said antibody as a therapeutic agent and/or preventative agent for cancer. The present invention provides an antibody that targets CAPRIN-1 polypeptides that are specifically expressed on the surface of cancer cells, and an application for the antibody as a therapeutic agent and/or preventative agent for cancer. Provided are an antibody that is immunologically reactive with CAPRIN1-protein and a fragment of said antibody, the antibody containing a heavy chain region including the complementarity determining regions of SEQ ID Nos. 1, 2 and 3, and a light chain region including the complementarity determining regions of SEQ ID Nos. 4, 5 and 6. Further provided is a pharmaceutical composition for the treatment and/or prevention of cancer and having the antibody or fragment as an active ingredient thereof.

Inventors:
OKANO Fumiyoshi (Toray Industries Inc., 10-1, Tebiro 6-chome, Kamakura-sh, Kanagawa 55, 〒2488555, JP)
SAITO Takanori (Toray Industries Inc., 10-1, Tebiro 6-chome, Kamakura-sh, Kanagawa 55, 〒2488555, JP)
MINAMIDA Yoshitaka (Toray Industries Inc., 10-1, Tebiro 6-chome, Kamakura-sh, Kanagawa 55, 〒2488555, JP)
IDO Takayoshi (Toray Industries Inc., 10-1, Tebiro 6-chome, Kamakura-sh, Kanagawa 55, 〒2488555, JP)
Application Number:
JP2014/071094
Publication Date:
February 12, 2015
Filing Date:
August 08, 2014
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
TORAY INDUSTRIES, INC. (1-1 Nihonbashi-Muromachi 2-chome, Chuo-ku Tokyo, 66, 〒1038666, JP)
International Classes:
C07K16/18; A61K39/395; A61K45/00; A61P35/00; A61P35/02; C07K16/46; C12N15/09; C12P21/08
Domestic Patent References:
WO2010016526A12010-02-11
WO2011096517A12011-08-11
WO2013018886A12013-02-07
WO2009113742A12009-09-17
WO2010016526A12010-02-11
WO2011096517A12011-08-11
WO2011096528A12011-08-11
WO2011096519A12011-08-11
WO2011096533A12011-08-11
WO2011096534A12011-08-11
WO2011096535A12011-08-11
WO2013018886A12013-02-07
WO2013018894A12013-02-07
WO2013018892A12013-02-07
WO2013018891A12013-02-07
WO2013018889A12013-02-07
WO2013018883A12013-02-07
WO2013125636A12013-08-29
WO2013125654A12013-08-29
WO2013125630A12013-08-29
WO2013125640A12013-08-29
WO2013147169A12013-10-03
WO2013147176A12013-10-03
WO1998046777A11998-10-22
WO1996002576A11996-02-01
WO1999051743A11999-10-14
WO2004063351A22004-07-29
WO2011120135A12011-10-06
WO2011005481A12011-01-13
WO2005063351A12005-07-14
WO2010018883A12010-02-18
Foreign References:
JP2013502205A2013-01-24
JP2013505028A2013-02-14
JP2013166164A2013-08-29
JP2007530068A2007-11-01
EP0239400A21987-09-30
US8388955B22013-03-05
US6737056B12004-05-18
US6602684B12003-08-05
EP1914244A22008-04-23
US7579170B22009-08-25
US8642292B22014-02-04
Other References:
See also references of EP 3031826A4
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
"Protein Chemistry IV, Chemical Modification and Peptide Synthesis", 1981, TOKYO KAGAKU DOJIN CO., LTD., article "Seikagaku Jikken Koza 1"
SAMBROOK ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1995, JOHN WILEY & SONS
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
GROTH, S.F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, I.S., J.EXP.MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER, G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
CARL, A.K. BORREBAECK; JAMES, W. LARRICK: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
SATO K. ET AL., CANCER RESEARCH, vol. 53, 1993, pages 851 - 856
HASHIMOTO-GOTOH, T. ET AL., GENE, vol. 152, 1995, pages 271 - 275
ZOLLER, MJ.; SMITH, M., METHODS ENZYMOL., vol. 100, 1983, pages 468 - 500
KRAMER, W. ET AL., NUCLEIC ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER, W.; FRITZ, HJ., METHODS ENZYMOL., vol. 154, 1987, pages 350 - 367
KUNKEL, TA., PROC. NATL. ACAD. SCI. USA., vol. 82, 1985, pages 488 - 492
KUNKEL, METHODS ENZYMOL., vol. 85, 1988, pages 2763 - 2766
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NATIONAL INSTITUTE OF HEALTH
SAMBROOK ET AL.: "Molecular Cloning A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
G.-B. KIM ET AL., PROTEIN ENGINEERING DESIGN AND SELECTION, vol. 20, no. 9, 2007, pages 425 - 432
P.J. DELVES.: "ANTIBODY PRODUCTION ESSENTIAL TECHNIQUES", 1997, WILEY
P. SHEPHERD; C. DEAN.: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: principles and practice", 1993, ACADEMIC PRESS
HIDEO SAJI, YAKUGAKU ZASSHI, vol. 128, no. 3, August 2008 (2008-08-01), pages 323 - 332
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (Atago Green Hills MORI Tower 32F, 5-1 Atago 2-chome, Minato-k, Tokyo 32, 〒1056232, JP)
Download PDF: