Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF FIBROTIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/167336
Kind Code:
A1
Abstract:
This pharmaceutical composition for treatment or prevention of fibrotic disease contains nucleic acid that inhibits the expression of mRNA encoding P4HA3. The fibrotic disease may be at least one disease selected from the group consisting of fibrosis, cirrhosis, renal failure, myocardial infarction, and cancer. The present invention provides a method for preventing or treating fibrotic disease, the method including administering an effective amount of the pharmaceutical composition according to the present invention to a subject who has, or is at risk of contracting, fibrotic disease.
Inventors:
NAKAYA MICHIO (JP)
Application Number:
PCT/JP2023/008195
Publication Date:
September 07, 2023
Filing Date:
March 03, 2023
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K31/713; A61K9/127; A61K31/7088; A61K48/00; A61P1/16; A61P9/04; A61P9/10; A61P13/12; A61P35/00; A61P43/00; C12N15/113
Domestic Patent References:
| WO2021095828A1 | 2021-05-20 |
Foreign References:
| JP2007182448A | 2007-07-19 | |||
| JP2021514951A | 2021-06-17 |
Other References:
NAKASUKA FUMIE, TABATA SHO, SAKAMOTO TAKEHARU, HIRAYAMA AKIYOSHI, EBI HIROMICHI, YAMADA TADAAKI, UMETSU KO, OHISHI MAKI, UENO AYAN: "TGF-β-dependent reprogramming of amino acid metabolism induces epithelial–mesenchymal transition in non-small cell lung cancers", COMMUNICATIONS BIOLOGY, vol. 4, no. 1, 24 June 2021 (2021-06-24), pages 782, XP093088521, DOI: 10.1038/s42003-021-02323-7
LUO YONGFENG, XU WEI, CHEN HUI, WARBURTON DAVID, DONG RACHEL, QIAN BANGPING, SELMAN MOISÉS, GAULDIE JACK, KOLB MARTIN, SHI WEI: "A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells : Mesenchymal TGFβ signalling and prolyl hydroxylase in lung fibrosis", THE JOURNAL OF PATHOLOGY, LONGMAN, HOBOKEN, USA, vol. 236, no. 3, 1 July 2015 (2015-07-01), Hoboken, USA, pages 384 - 394, XP093088522, ISSN: 0022-3417, DOI: 10.1002/path.4530
XIAO ZEZHOU, REDDY DESAI PAVAN KUMAR, XUE CHUQING, LIU XIMAO, CHEN XIONG, LI JIALE, LING XIAO, ZHENG SHAOYI: "Profiling of miR-205/P4HA3 Following Angiotensin II-Induced Atrial Fibrosis: Implications for Atrial Fibrillation", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 8, 26 April 2021 (2021-04-26), pages 609300, XP093088831, DOI: 10.3389/fcvm.2021.609300
LUO YONGFENG, XU WEI, CHEN HUI, WARBURTON DAVID, DONG RACHEL, QIAN BANGPING, SELMAN MOISÉS, GAULDIE JACK, KOLB MARTIN, SHI WEI: "A novel profibrotic mechanism mediated by TGFβ-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells : Mesenchymal TGFβ signalling and prolyl hydroxylase in lung fibrosis", THE JOURNAL OF PATHOLOGY, LONGMAN, HOBOKEN, USA, vol. 236, no. 3, 1 July 2015 (2015-07-01), Hoboken, USA, pages 384 - 394, XP093088522, ISSN: 0022-3417, DOI: 10.1002/path.4530
XIAO ZEZHOU, REDDY DESAI PAVAN KUMAR, XUE CHUQING, LIU XIMAO, CHEN XIONG, LI JIALE, LING XIAO, ZHENG SHAOYI: "Profiling of miR-205/P4HA3 Following Angiotensin II-Induced Atrial Fibrosis: Implications for Atrial Fibrillation", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 8, 26 April 2021 (2021-04-26), pages 609300, XP093088831, DOI: 10.3389/fcvm.2021.609300
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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