Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF HEPATITIS C
Document Type and Number:
WIPO Patent Application WO/2016/076441
Kind Code:
A1
Abstract:
The present invention can induce stronger cellular immunity to hepatitis C and provide a treatment means and a prevention means that are effective in completely eliminating the hepatitis C virus (HCV). Provided is a pharmaceutical composition for the treatment and/or prevention of hepatitis C, said composition comprising a recombinant vaccinia virus (a) and a recombinant vector (b) and characterized in that after one of the recombinant vaccinia virus (a) and the recombinant vector (b) is administered for initial immunity, the other is administered for additional immunity. The recombinant vaccinia virus (a) contains an expression promoter and all or a portion of the cDNA of the HCV genome. The recombinant vector (b) contains an expression promoter and all or a portion of the cDNA of the HCV (where the cDNA contained in the recombinant vector (b) has a different base sequence than that included in the recombinant vaccinia virus (a)).
Inventors:
KOHARA MICHINORI (JP)
YASUTOMI YASUHIRO (JP)
SHIOGAMA YUMIKO (JP)
YASUTOMI YASUHIRO (JP)
SHIOGAMA YUMIKO (JP)
Application Number:
PCT/JP2015/082327
Publication Date:
May 19, 2016
Filing Date:
November 11, 2015
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
NAT INST OF BIOMEDICAL INNOVATION HEALTH AND NUTRITION (JP)
CHEMO SERO THERAPEUT RES INST (JP)
NAT INST OF BIOMEDICAL INNOVATION HEALTH AND NUTRITION (JP)
CHEMO SERO THERAPEUT RES INST (JP)
International Classes:
A61K35/76; A61K31/7088; A61K39/29; A61P1/16; A61P31/14; C12N7/01; C12N15/09
Foreign References:
| US20110275139A1 | 2011-11-10 |
Other References:
ANNE FOURNILLIER ET AL.: "A Heterologous Prime/Boost VaccinationStrategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus", THE JOURNAL OF INFECTIOUS DISEASES, vol. 208, no. 6, 2013, pages 1008 - 19, XP055441226, ISSN: 0022-1899
TAKESHI WADA ET AL.: "DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model", VACCINE, vol. 31, no. 50, 2013, pages 5968 - 74, XP028776483, ISSN: 0264-410X
YAO DENG ET AL.: "Induction of Broadly Neutralising HCV Antibodies in Mice by Integration-Deficient Lentiviral Vector-Based Pseudotyped Particles", PLOS ONE, vol. 8, no. 4, 2013, pages e62684, 1 - 7, XP055381180, ISSN: 1932-6203
YUKIO KOIDE ET AL.: "DNA Vaccine ni yoru Kansen Bogyo", BLOOD IMMUNITY CANCER, vol. 7, no. 4, 2002, pages 372 - 384, XP009502891, ISSN: 1341-5824
YUMIKO SHIOGAMA ET AL.: "C-gata Kan'en Virus ni Taisuru DNA Vaccine to Kumikae Vaccinia Virus o Mochiita Prime/Boost-ho ni yoru Kan'en Virus Tokuiteki Men'eki Fukatsuka Koka no Kento", THE 18TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR VACCINOLOGY PROGRAM SHOROKUSHU, vol. 18 th, 6 December 2014 (2014-12-06), pages 127, XP009502935
See also references of EP 3219323A4
TAKESHI WADA ET AL.: "DNA vaccine expressing the non-structural proteins of hepatitis C virus diminishes the expression of HCV proteins in a mouse model", VACCINE, vol. 31, no. 50, 2013, pages 5968 - 74, XP028776483, ISSN: 0264-410X
YAO DENG ET AL.: "Induction of Broadly Neutralising HCV Antibodies in Mice by Integration-Deficient Lentiviral Vector-Based Pseudotyped Particles", PLOS ONE, vol. 8, no. 4, 2013, pages e62684, 1 - 7, XP055381180, ISSN: 1932-6203
YUKIO KOIDE ET AL.: "DNA Vaccine ni yoru Kansen Bogyo", BLOOD IMMUNITY CANCER, vol. 7, no. 4, 2002, pages 372 - 384, XP009502891, ISSN: 1341-5824
YUMIKO SHIOGAMA ET AL.: "C-gata Kan'en Virus ni Taisuru DNA Vaccine to Kumikae Vaccinia Virus o Mochiita Prime/Boost-ho ni yoru Kan'en Virus Tokuiteki Men'eki Fukatsuka Koka no Kento", THE 18TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR VACCINOLOGY PROGRAM SHOROKUSHU, vol. 18 th, 6 December 2014 (2014-12-06), pages 127, XP009502935
See also references of EP 3219323A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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