Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF NASH
Document Type and Number:
WIPO Patent Application WO/2017/086430
Kind Code:
A1
Abstract:
Provided is a medicinal use of an LPA1 antagonist, for example, an α halogen-substituted thiophene compound having a specific structure, or a pharmacologically acceptable salt thereof, as a drug for the treatment and/or prophylaxis of NASH. Provided is a pharmaceutical composition for treatment and/or prophylaxis of NASH, the composition having, as an active ingredient, an LPA1 antagonist, for example, a compound represented by general formula (I): [in the formula, R1 indicates a hydrogen atom or a methoxy group; R2 indicates a hydrogen atom or a C1-C6 alkyl group; X indicates a halogen atom; and A indicates a group selected from the group consisting of groups (II)] or a pharmacologically acceptable salt thereof.
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Inventors:
NISHIKAWA KENJI (JP)
MATSUNAGA HIROFUMI (JP)
SHINOHARA YUUKO (JP)
OKANARI EIJI (JP)
USHIYAMA SHIGERU (JP)
NONOUCHI SHINPEI (JP)
MATSUNAGA HIROFUMI (JP)
SHINOHARA YUUKO (JP)
OKANARI EIJI (JP)
USHIYAMA SHIGERU (JP)
NONOUCHI SHINPEI (JP)
Application Number:
PCT/JP2016/084227
Publication Date:
May 26, 2017
Filing Date:
November 18, 2016
Export Citation:
Assignee:
UBE INDUSTRIES (JP)
International Classes:
A61K45/00; A61K31/381; A61P1/16; A61P43/00; C07D333/36
Domestic Patent References:
| WO2014104372A1 | 2014-07-03 | |||
| WO2012138648A1 | 2012-10-11 | |||
| WO2014145873A2 | 2014-09-18 |
Foreign References:
| JP2012512178A | 2012-05-31 |
Other References:
MADIREDDI, MALAVI ET AL.: "Anti-Fibrotic Effect of Autotaxin and LPA1R Antagonists in a Rodent Model of NASH", HEPATOLOGY, vol. 62, no. S1, October 2015 (2015-10-01), pages 280A - 281A, XP 009510800
NISHIKAWA, KENJI ET AL: "Anti-fibrotic and anti-inflammatory effect of a novel LPA1 receptor antagonist, UD-009, in a mouse model of NASH ", HEPATOLOGY, vol. 64, no. 1, October 2016 (2016-10-01), pages 831A, XP009511096
PARRILL, ABBY L. ET AL.: "Sphingosine 1- phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands", SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 15, no. 5, 2004, pages 467 - 476, XP 055383306
TERAKADO, MASAHIKO ET AL.: "Discovery of ONO- 7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 10, August 2016 (2016-08-01), pages 913 - 918, XP 055379529
See also references of EP 3378491A4
NISHIKAWA, KENJI ET AL: "Anti-fibrotic and anti-inflammatory effect of a novel LPA1 receptor antagonist, UD-009, in a mouse model of NASH ", HEPATOLOGY, vol. 64, no. 1, October 2016 (2016-10-01), pages 831A, XP009511096
PARRILL, ABBY L. ET AL.: "Sphingosine 1- phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands", SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, vol. 15, no. 5, 2004, pages 467 - 476, XP 055383306
TERAKADO, MASAHIKO ET AL.: "Discovery of ONO- 7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead", ACS MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 10, August 2016 (2016-08-01), pages 913 - 918, XP 055379529
See also references of EP 3378491A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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