Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF TUMOR OR CANCER, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/233102
Kind Code:
A1
Abstract:
Provided are a pharmaceutical composition for treatment of a tumor or cancer, and an application thereof. The pharmaceutical composition comprises an oncolytic rhabdovirus and a CD38 small molecule inhibitor such as rhein by means of direct local injection or systemic administration or intratumoral delivery. The oncolytic rhabdovirus has the property of recognizing tumor cells and would not cause damage to normal cells; moreover, the CD38 small molecule inhibitor can specifically inhibit the activity of T-cell receptor molecules; the use of the oncolytic rhabdovirus and the CD38 small molecule inhibitor in combination has significant advantages in safety and efficacy.
Inventors:
QIN XIAOFENG (CN)
WU FEI (CN)
WU FEI (CN)
Application Number:
PCT/CN2019/123567
Publication Date:
November 26, 2020
Filing Date:
December 06, 2019
Export Citation:
Assignee:
HANGZHOU EVERBRIGHT BIOLOGICS LTD (CN)
International Classes:
A61K35/766; A61K31/122; A61K35/768; A61P35/00; C12N7/00; C12R1/93
Foreign References:
| CN105456302A | 2016-04-06 | |||
| CN105456302A | 2016-04-06 | |||
| CN1769433A | 2006-05-10 | |||
| CN102858959A | 2013-01-02 |
Other References:
"GenBank accession number: ACK77582.1", GENBANK, 28 December 2012 (2012-12-28), DOI: 20200305003420Y
"GenBank accession number: FJ478454.1", GENBANK, 28 December 2012 (2012-12-28), DOI: 20200305003454Y
"GenBank accession number: FJ478454.1", GENBANK, 28 December 2012 (2012-12-28), DOI: 20200305003454Y
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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