Title:
PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTION OR TREATMENT OF LIFESTYLE RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/176879
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition for use in prevention or treatment of lifestyle related diseases including type-2 diabetes and obesity related diseases. As a solution to the problem, prepared is a pharmaceutical composition that is for use in prevention or treatment of lifestyle related diseases and that contains, as an active ingredient, a compound represented by formula (I) or a salt thereof.
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Inventors:
ARAKI EIICHI (JP)
TATEISHI HIROSHI (JP)
TOMA TSUGUMASA (JP)
FUJITA MIKAKO (JP)
ARAKAKI YUIICHI (JP)
KONDO TATSUYA (JP)
MIYAKAWA NOBUKAZU (JP)
OTSUKA MASAMI (JP)
TATEISHI HIROSHI (JP)
TOMA TSUGUMASA (JP)
FUJITA MIKAKO (JP)
ARAKAKI YUIICHI (JP)
KONDO TATSUYA (JP)
MIYAKAWA NOBUKAZU (JP)
OTSUKA MASAMI (JP)
Application Number:
PCT/JP2023/010060
Publication Date:
September 21, 2023
Filing Date:
March 15, 2023
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
SCIENCE FARM LTD (JP)
SCIENCE FARM LTD (JP)
International Classes:
A61K31/44; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P27/02; A61P27/06
Domestic Patent References:
| WO2020158890A1 | 2020-08-06 |
Other References:
VU HUY LUONG, TAKENAO CHINO, NORITAKA OYAMA, TAKASHI MATSUSHITA, YOKO SASAKI, DAI OGURA, SHIN-ICHIRO NIWA, TANIMA BISWAS, AKIYUKI : "Blockade of TGF-B/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis", ARTHRITIS RESEARCH & THERAPY, vol. 20, no. 1, 1 December 2018 (2018-12-01), XP055728582, DOI: 10.1186/s13075-018-1534-y
HANEDA, MASAKAZU: "Increase in the number of diabetic nephropathy patients and countermeasures", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 93, no. 5, 10 May 2004 (2004-05-10), JP , pages 1012 - 1016, XP009549000, ISSN: 0021-5384, DOI: 10.2169/naika.93.1012
SON YANG-JU, JUNG DA SEUL, SHIN JI MIN, KIM MYUNGSUK, YOO GYHYE, NHO CHU WON: "Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis", BMC COMPLEMENTARY MEDICINE AND THERAPIES, vol. 21, no. 1, 1 December 2021 (2021-12-01), XP093091364, DOI: 10.1186/s12906-021-03212-6
HOSONO, T. YOKOMIZO, K. HAMASAKI, A. OKAMOTO, Y. OKAWARA, T. OTSUKA, M. MUKAI, R. SUZUKI, K.: "Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 1, 24 October 2007 (2007-10-24), Amsterdam NL , pages 371 - 374, XP022410917, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.065
TOMA TSUGUMASA, TATEISHI HIROSHI, KAWAKAMI KENSAKU, ALI TAHA F. S., KAMO MASAHIRO, MONDE KAZUAKI, NAKASHIMA YUTA, FUJITA MIKAKO, O: "Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 9, pages 5047, XP093091365, DOI: 10.3390/ijms23095047
HANEDA, MASAKAZU: "Increase in the number of diabetic nephropathy patients and countermeasures", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 93, no. 5, 10 May 2004 (2004-05-10), JP , pages 1012 - 1016, XP009549000, ISSN: 0021-5384, DOI: 10.2169/naika.93.1012
SON YANG-JU, JUNG DA SEUL, SHIN JI MIN, KIM MYUNGSUK, YOO GYHYE, NHO CHU WON: "Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db/db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis", BMC COMPLEMENTARY MEDICINE AND THERAPIES, vol. 21, no. 1, 1 December 2021 (2021-12-01), XP093091364, DOI: 10.1186/s12906-021-03212-6
HOSONO, T. YOKOMIZO, K. HAMASAKI, A. OKAMOTO, Y. OKAWARA, T. OTSUKA, M. MUKAI, R. SUZUKI, K.: "Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 18, no. 1, 24 October 2007 (2007-10-24), Amsterdam NL , pages 371 - 374, XP022410917, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2007.10.065
TOMA TSUGUMASA, TATEISHI HIROSHI, KAWAKAMI KENSAKU, ALI TAHA F. S., KAMO MASAHIRO, MONDE KAZUAKI, NAKASHIMA YUTA, FUJITA MIKAKO, O: "Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 9, pages 5047, XP093091365, DOI: 10.3390/ijms23095047
Attorney, Agent or Firm:
FUJIMOTO Shohei (JP)
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