Title:
PHARMACEUTICAL COMPOSITION FOR USE IN TREATING COGNITIVE DECLINE, EXCESS WEIGHT, OR OBESITY
Document Type and Number:
WIPO Patent Application WO/2023/042887
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for use in treating cognitive decline. This pharmaceutical composition contains an antagonist of AMPA receptors. The present invention also provides a pharmaceutical composition for use in treating a disease or condition associated with NMDA refractoriness in an NMDA refractoriness subject. The present invention may be useful in a subject in whom, e.g., intracellular calcium influx due to stimulation by NMDA and glycine is inhibited in NMDA receptors in which suppression of activation by Mg ions is removed. The present invention further provides a pharmaceutical composition for use in treating excess weight and obesity.
Inventors:
ISHIUCHI SHOGO (JP)
Application Number:
PCT/JP2022/034601
Publication Date:
March 23, 2023
Filing Date:
September 15, 2022
Export Citation:
Assignee:
UNIV OF THE RYUKYUS (JP)
International Classes:
A61K45/00; A61K31/444; A61P3/04
Domestic Patent References:
| WO1996010023A1 | 1996-04-04 | |||
| WO2003082332A1 | 2003-10-09 | |||
| WO1995012594A1 | 1995-05-11 | |||
| WO1998017652A1 | 1998-04-30 | |||
| WO1997032858A1 | 1997-09-12 | |||
| WO1999006408A1 | 1999-02-11 | |||
| WO1996015100A1 | 1996-05-23 | |||
| WO1995021842A1 | 1995-08-17 | |||
| WO1999007707A1 | 1999-02-18 | |||
| WO1992007847A1 | 1992-05-14 |
Foreign References:
| US6191117B1 | 2001-02-20 | |||
| JP2010520154A | 2010-06-10 | |||
| JP2008538216A | 2008-10-16 | |||
| US6949571B2 | 2005-09-27 | |||
| LU73068A1 | 1976-07-01 | |||
| LU115445A1 | ||||
| US5639751A | 1997-06-17 | |||
| EP0283959A1 | 1988-09-28 | |||
| US20170015851W | 2017-01-31 |
Other References:
PATERNAIN ET AL., NEURON, vol. 14, 1995, pages 185 - 189
NEUROPHARMACOLOGY, vol. 37, 1998, pages 1211 - 1222
NEUROPHARMACOLOGY, vol. 61, no. 5-6, 2011, pages 1033 - 47
SAITO ET AL.: "Single App knock-in mouse models of Alzheimer's disease", NAT. NEUROSCI., vol. 17, 2014, pages 661 - 4
NAT. NEUROSCI., vol. 17, 2014, pages 661 - 4
CURR OPIN NEUROL, vol. 1, 2021, pages 266 - 274
DOECKE JD ET AL., NEUROLOGY, 2020
BREWER GJ ET AL., NAT PROTOC, vol. 2, 2007, pages 1490 - 1498
LAM AD ET AL., NAT MED, 2017
HOKAMA Y. ET AL., NEURO ONCOLOGY, 2022, pages noacl62
S. L. HARGRAVES. JONEST. L. DAVIDSON, CURR. OPIN. BEHAV. SCI., vol. 9, 2016, pages 7 14 - 46
L-L. HWANG, C-H. WANG, T-L. LI, S-D. CHANG, L-C. LIN, C-P. CHEN, C-T. CHEN, K-C. LIANG, 1-K. HO, W-S. YANG, L-C. CHIOU, OBESITY (SILVER SPRING, vol. 18, 2010, pages 463 - 469
1. VALLADOLID-ACEBES, P. STUCCHI, V. CANO, M. S. FERNANDEZ-ALFONSO, B. MERINO, M. GIL-ORTEGA, A. FOIE, L. MORALES, M. RUIZ-GAYO, N, NEUROBIOL. LEARN. MEM., vol. 95, 2011, pages 80 - 85
M. FOTUHID. DOC. JACK, NAT. REV. NEUROL., vol. 8, 2012, pages 189 - 202
N. D. OLMOM. RUIZ-GAYO, FRONT. CELL. NEUROSCI., vol. 12, 2018, pages 439
M. ANAI, M. FUNAKI, T. OGIHARA, A. KANDA, Y. ONISHI, H. SAKODA, K. INUKAI, M. NAWANO, Y. FUKUSHIMA, Y. YAZAKI, M. KIKUCHI, Y. OKA,, DIABETES, vol. 48, 1999, pages 158 - 169
S. HIBI, K. UENO, S. NAGATO, K. KAWANO, K. ITO, Y. NORIMINE, O. TAKENAKA, T. HANADA, M. YONAGA, J. MED. CHEM., vol. 55, 2012, pages 10584 - 10600
A. ROZOVN. BURNASHEV, CELL CALCIUM, vol. 60, 2016, pages 407 - 414
S. ISHIUCHI, K. TSUZUKI, Y. YOSHIDA, N. YAMADA, N. HAGIMURA, H. OKADO, A. MIWA, H. KURIHARA Y. NAKAZATO, M. TAMURA, T. SASAKI, S. , NAT. MED., vol. 8, 2002, pages 971 - 978
M. AKAMATSUT. YAMASHITAN. HIROSES. TERAMOTOS. KWAK, SCI. REP., vol. 6, 2016, pages 29649
K. L. CONRAD, K. Y. TSENG, J. L. UEJIMA, J. M. REIMERS, L-J. HENG, Y. SHAHAM, M. MARINELLI, M. E. WOLF, NATURE, vol. 454, 2008, pages 118 - 121
R. K. KHANGURAA. BALIA. S. JAGGI, EUR. J. PHARMACOL., vol. 795, 2017, pages 36 - 42
J. A. FRENCH, C. L. KRAUSS, R. T, WECHSLER, X-F. WANG, B. DIVENTURA, C. BRANDT, E. TRINKA, T. J. O BRIEN, A. LAURENZA, A. PATTEN, , NEUROLOGY, vol. 85, 2015, pages 950 - 957
S. CULL-CANDYL. KELLYM. FARRANT, CURR. OPIN. NEUROBIOL., vol. 16, 2006, pages 288 - 297
S. J. LIUR. S. ZUKIN, TRENDS NEUROSCI., vol. 30, 2007, pages 126 - 134
S. OZAWA, J. PHYSIOL., vol. 587, 2009, pages 1861 - 1862
E. IWAMURAK. YAMADAY. ICHITANI, BEHAV. BRAIN RES., vol. 307, 2016, pages 92 - 99
F. L. HITTIS. A. SIEGELBAUM, NATURE, vol. 508, 2014, pages 88 - 92
B. MEIF. LIY. GUZ. CUIJ. Z. TSIEN, PLOS ONE, vol. 6, 2011, pages e19326
C. PORREROP. RUBIO-GARRIDOC. AVENDANOF. CLASCÁ, BRAIN RES., vol. 1345, 2010, pages 59 - 72
K. CHUNG, J. WALLACE, S-Y. KIM, S. KATYANASUNDAMM, A. S. ANDALMAN, T. J. DAVIDSON, .1. J. MIRZABEKOV, K. A. ZALOCUSKY, J. MATTIS, , NATURE, vol. 497, 2013, pages 332 - 337
Y. ZHANGR. PROENCAM. MAFFEIM. BARONEL. LEOPOLDJ. M. FRIEDMAN, NATURE, vol. 372, 1994, pages 425 - 432
C. T. MONTAGUE, I. S. FAROOQI, J. P. WHITEHEAD, M. A. SOOS, H. RAU, N. J. WAREHAM, C. P. SEWTER, J. E. DIGBY, S. N. MOHAMMED, J. A, NATURE, vol. 397, 1997, pages 903 - 908
L. J. SHANLEYA. J. IRVINGJ. HARVEY, J. NEUROSCI., vol. 21, 2001, pages RC186
R. MAZOR, D. FRIEDMANN-MORVINSKI, T. ALSAIGH, Q. KLEIFELD, E. B. KISTLER, L. ROUSSO-NOORI, C. HUANG, J. B. LI, 1. M. VERMA, G. W. , SCI. TRANSL, MED., vol. 10, 2018, pages 6324
R. BRUSAF. ZIMMERMANND.-S. KOHD. FELDMEYERP. GASSP. N. SEEBURGR. SPRENGEL, SCIENCE, vol. 270, 1995, pages 1677 - 1680
S. J. SAWIAKN. 1. WOODG. E3. WILLIAMSA. J. MORTONT. A. CARPENTER, NEUROBIOL. DIS., vol. 33, 2009, pages 20 - 27
G. J. PAZ-FILHO, NEURALPLAST., 2016
A. V. WITTE, T. KOBE, A. GRANNKE, J. P. SCHUCHARDT, A. HAHN, V. A. TESKY, J. PANTEL, A. FLOEL, BRAIN MAPP., vol. 37, 2016, pages 4539 - 4549
A. E. DORRJ. P. LERCHS. SPRINGN. KABANIR. M. HENKELMAN, NEUROIMAGE, vol. 42, 2008, pages 60 - 69
A. SHIROMA, M. NISHIMURA, H. NAGAMINE, T. MIYAGI, Y. HOKAMA, T. WATANABE, S. MURAYAMA, M. TSUTSUI, D. TOMINAGA, S. ISHIUCHI, CEREBELLUM, vol. 15, 2016, pages 645 - 662
R. USUGIM. NISHIMURAS. ISHIUCHI, BRAIN BEHAV., vol. 10, 2020, pages e01878
J. F. GUZOWSKIJ. J. KNIERIMΓ. T. MOSER, NEURON, vol. 44, 2004, pages 581 - 584
T. SASAKIS. MATSUIT. KITAMURA, INT. J. MOL. SCI., vol. 17, 2016, pages 1081
C. LIISCHERR. C. MALENKA, COLD SPRING HARB. PERSPECT. BIOL., vol. 4, 2012, pages a005710
S. E. KANOSKIT. L. DAVIDSON, PHYSIOL. BEHAV., vol. 103, 2011, pages 59 - 68
L. B. HASSINGA. K. DAHLN. L. PEDERSENB. JOHANSSON, DEMENT. GERIATR. COGN. DISORD., vol. 29, 2010, pages 543 - 552
W. JAGUSTD. HARVEYD. MUNGASM. HAAN, ARCH. NEURAL, vol. 62, 2005, pages 1545 - 1548
K. F. YATESV. SWEATP. L. YAUM. M. TURCHIANOA. CONVIT, ARTERIOSCLER. THROMB. VASE. BIOL., vol. 32, 2012, pages 2060 - 2067
P. G. KOPELMAN, NATURE, vol. 404, 2000, pages 635 - 643
B. RASHID, S. I. DEV, M. NICOLETTE, F. SCHWARZ, T. FERLAND, F. C. FORTENBAUGH, W. P. MILBERG, R. E. MCGLINCHEY, D. H. SALAT, F. C., BRAIN BEHAV., vol. 9, 2019, pages e01333
M. GESERICK, M. VOGEL, R. GAUSCHE, T. LIPEK, U. SPIELAU, E. KELLER, R. PFAFFLE, W. KIESS, A. KÖRNER, J. MED., vol. 379, 2018, pages 1303 - 1312
D. C. OU-YANGP. J. YORKC. J. KLECKV. V. PATEL, J. BONE JOINT SURG. AM., vol. 99, 2017, pages 2027 - 2036
T. YONEKAWA, M. C. V. MALICDAN, A. CHO, Y. K. HAYASHI, T. NONAKA, T. MINE, T. YAMAMOTO, 1. NISHINO, S. NOGUCHI., BRAIN, vol. 137, 2014, pages 2670 - 2679
H. AGETAA. MURAYAMAR. MIGISHIMAS. KIDAK. TSUCHIDAM. YOKOYAMAK. INOKUCHI, PLOS ONE, vol. 3, 2008, pages 1869
T-N. HUANGY. P. HSUEH, BIOPROTOCOL, vol. 4, 2014
T. TODAY. NODAG. ITOM. MAEDAT. SHIMIZU, J. BIOMED. BIOTECHNOL., 2011, pages 617974
T. NAKASHIBAJ. D. CUSHMANK. A. POLKEYC. J. MCBAINM. S. FANSELOWS. TONEGAWA, CELL, vol. 149, 2012, pages 188 - 201
W. B. CHWANGK. J. O † RIORDANJ. M. LEVENSONJ. D. SWEATT, LEARN. MEM., vol. 13, 2006, pages 322 - 328
J. P. P. ULLMANNC. WATSONA. L. JANKEN. D. KUMIAWAND. C. REUTENS, NEUROIMAGE, vol. 78, 2013, pages 196 - 203
T. L. RICHARDST. J. GRABOWSKIP. BOORDK. YAGLEM. ASKRENZ. MESTREP. ROBINSONO. WELKERD. GULLIFORDW. NAGY, NEUROIMAGE CLIN., vol. 8, 2015, pages 408 - 421
S. WHITFIELD-GABRIELIA. NIETO-CASTANON, BRAIN CONNECT., vol. 2, 2012, pages 125 - 141
M. RUBINOVO. SPORNS, NEUROIMAGE, vol. 52, 2010, pages 1059 - 1069
M. XIAJ. WANGY. HE, PLOS ONE, vol. 8, 2013, pages e68910
I. VAO, H. TAKAGI, H. AGETA, T. KAL)YO, S. SATO, K. HATANAKA, Y. FUKUDA, T. CHIBA, N. MORONE, S. YUASA, K. INOKUCHI, T. OHTSUKA, G, CELL, vol. 130, 2007, pages 943 - 957
H. TAKAGIM. SETOUS. ITO1. YAO, NEURAL.PLAST., 2012, pages 352829
L. NOWAKP. BREGESTOVSKIP. ASCHERA. HERBETA. PROCHIANTZ, NATURE, vol. 307, 1984, pages 462 - 465
M. KOIKEM. LINOS. OZAWA, NEUROSCI. RES., vol. 29, 1997, pages 27 - 36
A. C. BOUDREAUJ. M. REIMERSM. MILOVANOVICM. E. WOLF, J. NEUROSCI., vol. 27, 2007, pages 10621 - 10635
0. H. LOWRYN. J. ROSEBROUGHA. L. FARRR. J. RANDALL, J. BIOL. CHEM., vol. 193, 1951, pages 265 - 275
J. B. TREWEEKK. Y. CHANN. C. FLYTZANISB. YANGB. E. DEVERMANA. GREENBAUMA. LIGNELLC. XIAOL. CAIM. S. LADINSKY, NAT. PROTOC., vol. 10, 2015, pages 1860 - 1896
G. FENG, R. H. MELLOR, M. BERNSTEIN, C. KELLER-PECK, Q. T. NGUYEN, M. WALLACE, J. M. NERBONNE, J. W. LICHTMAN, J. R. SANES, NEURON, vol. 28, 2000, pages 41 - 51
D. KIMJ. M. PAGGIC. PARKC. R. BENNETTS. L. SALZBERG, BIOTECHNOL., vol. 37, 2019, pages 907 - 915
R. PATROG. DUGGALM. I. LOVER. A. IRIZARRYC. KINGSFORD, NAT METHODS, vol. 14, 2017, pages 417 - 419
M. PERTEA, G. M. PERTEA, C. M. ANTONESCU, T. C. CHANG, J. T. MENDELL, S. L. SATZBERG, BIOTECHNOL., vol. 33, 2015, pages 290 - 295
M. A. DEPRISTO, E. BANKS, R, POPLIN, K. V. GARIMELLA, J. R. MAGUIRE, C. HARTL, A. A. PHILIPPAKIS, G. DEL ANGEL, M. A. RIVAS, M. HA, NUT. GENET., vol. 43, 2011, pages 491 - 498
G. A. VAN DER AUWERA, M. O. CARNEIRO, C. HARTL, R. POPLIN, G. DELANGEL., A. LEVY-MOONSHINE, T. JORDAN., K. SHAKIR, D. ROAZEN, J. T, CURR. PROTOC. BIOINFORMATICS, vol. 43, 2013
A. MCKENNAM. HANNAE. BANKSA. SIVACHENKOK. CIBULSKISA. KERNYTSKYK. GARIMELLAD. ALTSHULERS. GABRIELM. DALY, GENOME RES., vol. 20, 2010, pages 1297 - 1303
P. CINGOLANI, A. PLATTS, L. L. WANG, M. COON, T. NGUYEN, L. WANG, S. J. LAND, X. LU, D. M. RUDEN, FLY, vol. 6, 2012, pages 80 - 92
K. A. YAMADA, NEUROBIOLOGY OF DISEASE, vol. 5, 1998, pages 67 - 80
NEUROPHARMACOLOGY, vol. 37, 1998, pages 1211 - 1222
NEUROPHARMACOLOGY, vol. 61, no. 5-6, 2011, pages 1033 - 47
SAITO ET AL.: "Single App knock-in mouse models of Alzheimer's disease", NAT. NEUROSCI., vol. 17, 2014, pages 661 - 4
NAT. NEUROSCI., vol. 17, 2014, pages 661 - 4
CURR OPIN NEUROL, vol. 1, 2021, pages 266 - 274
DOECKE JD ET AL., NEUROLOGY, 2020
BREWER GJ ET AL., NAT PROTOC, vol. 2, 2007, pages 1490 - 1498
LAM AD ET AL., NAT MED, 2017
HOKAMA Y. ET AL., NEURO ONCOLOGY, 2022, pages noacl62
S. L. HARGRAVES. JONEST. L. DAVIDSON, CURR. OPIN. BEHAV. SCI., vol. 9, 2016, pages 7 14 - 46
L-L. HWANG, C-H. WANG, T-L. LI, S-D. CHANG, L-C. LIN, C-P. CHEN, C-T. CHEN, K-C. LIANG, 1-K. HO, W-S. YANG, L-C. CHIOU, OBESITY (SILVER SPRING, vol. 18, 2010, pages 463 - 469
1. VALLADOLID-ACEBES, P. STUCCHI, V. CANO, M. S. FERNANDEZ-ALFONSO, B. MERINO, M. GIL-ORTEGA, A. FOIE, L. MORALES, M. RUIZ-GAYO, N, NEUROBIOL. LEARN. MEM., vol. 95, 2011, pages 80 - 85
M. FOTUHID. DOC. JACK, NAT. REV. NEUROL., vol. 8, 2012, pages 189 - 202
N. D. OLMOM. RUIZ-GAYO, FRONT. CELL. NEUROSCI., vol. 12, 2018, pages 439
M. ANAI, M. FUNAKI, T. OGIHARA, A. KANDA, Y. ONISHI, H. SAKODA, K. INUKAI, M. NAWANO, Y. FUKUSHIMA, Y. YAZAKI, M. KIKUCHI, Y. OKA,, DIABETES, vol. 48, 1999, pages 158 - 169
S. HIBI, K. UENO, S. NAGATO, K. KAWANO, K. ITO, Y. NORIMINE, O. TAKENAKA, T. HANADA, M. YONAGA, J. MED. CHEM., vol. 55, 2012, pages 10584 - 10600
A. ROZOVN. BURNASHEV, CELL CALCIUM, vol. 60, 2016, pages 407 - 414
S. ISHIUCHI, K. TSUZUKI, Y. YOSHIDA, N. YAMADA, N. HAGIMURA, H. OKADO, A. MIWA, H. KURIHARA Y. NAKAZATO, M. TAMURA, T. SASAKI, S. , NAT. MED., vol. 8, 2002, pages 971 - 978
M. AKAMATSUT. YAMASHITAN. HIROSES. TERAMOTOS. KWAK, SCI. REP., vol. 6, 2016, pages 29649
K. L. CONRAD, K. Y. TSENG, J. L. UEJIMA, J. M. REIMERS, L-J. HENG, Y. SHAHAM, M. MARINELLI, M. E. WOLF, NATURE, vol. 454, 2008, pages 118 - 121
R. K. KHANGURAA. BALIA. S. JAGGI, EUR. J. PHARMACOL., vol. 795, 2017, pages 36 - 42
J. A. FRENCH, C. L. KRAUSS, R. T, WECHSLER, X-F. WANG, B. DIVENTURA, C. BRANDT, E. TRINKA, T. J. O BRIEN, A. LAURENZA, A. PATTEN, , NEUROLOGY, vol. 85, 2015, pages 950 - 957
S. CULL-CANDYL. KELLYM. FARRANT, CURR. OPIN. NEUROBIOL., vol. 16, 2006, pages 288 - 297
S. J. LIUR. S. ZUKIN, TRENDS NEUROSCI., vol. 30, 2007, pages 126 - 134
S. OZAWA, J. PHYSIOL., vol. 587, 2009, pages 1861 - 1862
E. IWAMURAK. YAMADAY. ICHITANI, BEHAV. BRAIN RES., vol. 307, 2016, pages 92 - 99
F. L. HITTIS. A. SIEGELBAUM, NATURE, vol. 508, 2014, pages 88 - 92
B. MEIF. LIY. GUZ. CUIJ. Z. TSIEN, PLOS ONE, vol. 6, 2011, pages e19326
C. PORREROP. RUBIO-GARRIDOC. AVENDANOF. CLASCÁ, BRAIN RES., vol. 1345, 2010, pages 59 - 72
K. CHUNG, J. WALLACE, S-Y. KIM, S. KATYANASUNDAMM, A. S. ANDALMAN, T. J. DAVIDSON, .1. J. MIRZABEKOV, K. A. ZALOCUSKY, J. MATTIS, , NATURE, vol. 497, 2013, pages 332 - 337
Y. ZHANGR. PROENCAM. MAFFEIM. BARONEL. LEOPOLDJ. M. FRIEDMAN, NATURE, vol. 372, 1994, pages 425 - 432
C. T. MONTAGUE, I. S. FAROOQI, J. P. WHITEHEAD, M. A. SOOS, H. RAU, N. J. WAREHAM, C. P. SEWTER, J. E. DIGBY, S. N. MOHAMMED, J. A, NATURE, vol. 397, 1997, pages 903 - 908
L. J. SHANLEYA. J. IRVINGJ. HARVEY, J. NEUROSCI., vol. 21, 2001, pages RC186
R. MAZOR, D. FRIEDMANN-MORVINSKI, T. ALSAIGH, Q. KLEIFELD, E. B. KISTLER, L. ROUSSO-NOORI, C. HUANG, J. B. LI, 1. M. VERMA, G. W. , SCI. TRANSL, MED., vol. 10, 2018, pages 6324
R. BRUSAF. ZIMMERMANND.-S. KOHD. FELDMEYERP. GASSP. N. SEEBURGR. SPRENGEL, SCIENCE, vol. 270, 1995, pages 1677 - 1680
S. J. SAWIAKN. 1. WOODG. E3. WILLIAMSA. J. MORTONT. A. CARPENTER, NEUROBIOL. DIS., vol. 33, 2009, pages 20 - 27
G. J. PAZ-FILHO, NEURALPLAST., 2016
A. V. WITTE, T. KOBE, A. GRANNKE, J. P. SCHUCHARDT, A. HAHN, V. A. TESKY, J. PANTEL, A. FLOEL, BRAIN MAPP., vol. 37, 2016, pages 4539 - 4549
A. E. DORRJ. P. LERCHS. SPRINGN. KABANIR. M. HENKELMAN, NEUROIMAGE, vol. 42, 2008, pages 60 - 69
A. SHIROMA, M. NISHIMURA, H. NAGAMINE, T. MIYAGI, Y. HOKAMA, T. WATANABE, S. MURAYAMA, M. TSUTSUI, D. TOMINAGA, S. ISHIUCHI, CEREBELLUM, vol. 15, 2016, pages 645 - 662
R. USUGIM. NISHIMURAS. ISHIUCHI, BRAIN BEHAV., vol. 10, 2020, pages e01878
J. F. GUZOWSKIJ. J. KNIERIMΓ. T. MOSER, NEURON, vol. 44, 2004, pages 581 - 584
T. SASAKIS. MATSUIT. KITAMURA, INT. J. MOL. SCI., vol. 17, 2016, pages 1081
C. LIISCHERR. C. MALENKA, COLD SPRING HARB. PERSPECT. BIOL., vol. 4, 2012, pages a005710
S. E. KANOSKIT. L. DAVIDSON, PHYSIOL. BEHAV., vol. 103, 2011, pages 59 - 68
L. B. HASSINGA. K. DAHLN. L. PEDERSENB. JOHANSSON, DEMENT. GERIATR. COGN. DISORD., vol. 29, 2010, pages 543 - 552
W. JAGUSTD. HARVEYD. MUNGASM. HAAN, ARCH. NEURAL, vol. 62, 2005, pages 1545 - 1548
K. F. YATESV. SWEATP. L. YAUM. M. TURCHIANOA. CONVIT, ARTERIOSCLER. THROMB. VASE. BIOL., vol. 32, 2012, pages 2060 - 2067
P. G. KOPELMAN, NATURE, vol. 404, 2000, pages 635 - 643
B. RASHID, S. I. DEV, M. NICOLETTE, F. SCHWARZ, T. FERLAND, F. C. FORTENBAUGH, W. P. MILBERG, R. E. MCGLINCHEY, D. H. SALAT, F. C., BRAIN BEHAV., vol. 9, 2019, pages e01333
M. GESERICK, M. VOGEL, R. GAUSCHE, T. LIPEK, U. SPIELAU, E. KELLER, R. PFAFFLE, W. KIESS, A. KÖRNER, J. MED., vol. 379, 2018, pages 1303 - 1312
D. C. OU-YANGP. J. YORKC. J. KLECKV. V. PATEL, J. BONE JOINT SURG. AM., vol. 99, 2017, pages 2027 - 2036
T. YONEKAWA, M. C. V. MALICDAN, A. CHO, Y. K. HAYASHI, T. NONAKA, T. MINE, T. YAMAMOTO, 1. NISHINO, S. NOGUCHI., BRAIN, vol. 137, 2014, pages 2670 - 2679
H. AGETAA. MURAYAMAR. MIGISHIMAS. KIDAK. TSUCHIDAM. YOKOYAMAK. INOKUCHI, PLOS ONE, vol. 3, 2008, pages 1869
T-N. HUANGY. P. HSUEH, BIOPROTOCOL, vol. 4, 2014
T. TODAY. NODAG. ITOM. MAEDAT. SHIMIZU, J. BIOMED. BIOTECHNOL., 2011, pages 617974
T. NAKASHIBAJ. D. CUSHMANK. A. POLKEYC. J. MCBAINM. S. FANSELOWS. TONEGAWA, CELL, vol. 149, 2012, pages 188 - 201
W. B. CHWANGK. J. O † RIORDANJ. M. LEVENSONJ. D. SWEATT, LEARN. MEM., vol. 13, 2006, pages 322 - 328
J. P. P. ULLMANNC. WATSONA. L. JANKEN. D. KUMIAWAND. C. REUTENS, NEUROIMAGE, vol. 78, 2013, pages 196 - 203
T. L. RICHARDST. J. GRABOWSKIP. BOORDK. YAGLEM. ASKRENZ. MESTREP. ROBINSONO. WELKERD. GULLIFORDW. NAGY, NEUROIMAGE CLIN., vol. 8, 2015, pages 408 - 421
S. WHITFIELD-GABRIELIA. NIETO-CASTANON, BRAIN CONNECT., vol. 2, 2012, pages 125 - 141
M. RUBINOVO. SPORNS, NEUROIMAGE, vol. 52, 2010, pages 1059 - 1069
M. XIAJ. WANGY. HE, PLOS ONE, vol. 8, 2013, pages e68910
I. VAO, H. TAKAGI, H. AGETA, T. KAL)YO, S. SATO, K. HATANAKA, Y. FUKUDA, T. CHIBA, N. MORONE, S. YUASA, K. INOKUCHI, T. OHTSUKA, G, CELL, vol. 130, 2007, pages 943 - 957
H. TAKAGIM. SETOUS. ITO1. YAO, NEURAL.PLAST., 2012, pages 352829
L. NOWAKP. BREGESTOVSKIP. ASCHERA. HERBETA. PROCHIANTZ, NATURE, vol. 307, 1984, pages 462 - 465
M. KOIKEM. LINOS. OZAWA, NEUROSCI. RES., vol. 29, 1997, pages 27 - 36
A. C. BOUDREAUJ. M. REIMERSM. MILOVANOVICM. E. WOLF, J. NEUROSCI., vol. 27, 2007, pages 10621 - 10635
0. H. LOWRYN. J. ROSEBROUGHA. L. FARRR. J. RANDALL, J. BIOL. CHEM., vol. 193, 1951, pages 265 - 275
J. B. TREWEEKK. Y. CHANN. C. FLYTZANISB. YANGB. E. DEVERMANA. GREENBAUMA. LIGNELLC. XIAOL. CAIM. S. LADINSKY, NAT. PROTOC., vol. 10, 2015, pages 1860 - 1896
G. FENG, R. H. MELLOR, M. BERNSTEIN, C. KELLER-PECK, Q. T. NGUYEN, M. WALLACE, J. M. NERBONNE, J. W. LICHTMAN, J. R. SANES, NEURON, vol. 28, 2000, pages 41 - 51
D. KIMJ. M. PAGGIC. PARKC. R. BENNETTS. L. SALZBERG, BIOTECHNOL., vol. 37, 2019, pages 907 - 915
R. PATROG. DUGGALM. I. LOVER. A. IRIZARRYC. KINGSFORD, NAT METHODS, vol. 14, 2017, pages 417 - 419
M. PERTEA, G. M. PERTEA, C. M. ANTONESCU, T. C. CHANG, J. T. MENDELL, S. L. SATZBERG, BIOTECHNOL., vol. 33, 2015, pages 290 - 295
M. A. DEPRISTO, E. BANKS, R, POPLIN, K. V. GARIMELLA, J. R. MAGUIRE, C. HARTL, A. A. PHILIPPAKIS, G. DEL ANGEL, M. A. RIVAS, M. HA, NUT. GENET., vol. 43, 2011, pages 491 - 498
G. A. VAN DER AUWERA, M. O. CARNEIRO, C. HARTL, R. POPLIN, G. DELANGEL., A. LEVY-MOONSHINE, T. JORDAN., K. SHAKIR, D. ROAZEN, J. T, CURR. PROTOC. BIOINFORMATICS, vol. 43, 2013
A. MCKENNAM. HANNAE. BANKSA. SIVACHENKOK. CIBULSKISA. KERNYTSKYK. GARIMELLAD. ALTSHULERS. GABRIELM. DALY, GENOME RES., vol. 20, 2010, pages 1297 - 1303
P. CINGOLANI, A. PLATTS, L. L. WANG, M. COON, T. NGUYEN, L. WANG, S. J. LAND, X. LU, D. M. RUDEN, FLY, vol. 6, 2012, pages 80 - 92
K. A. YAMADA, NEUROBIOLOGY OF DISEASE, vol. 5, 1998, pages 67 - 80
Attorney, Agent or Firm:
MORITA Yutaka (JP)
Download PDF: