Title:
PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/051223
Kind Code:
A1
Abstract:
Disclosed herein are a pharmaceutical composition and use thereof. The pharmaceutical composition comprises an anti-CTLA4 and anti-PD-1 bispecific antibody and an anti-PD-1 and anti-VEGFA bispecific antibody. The pharmaceutical composition of the present invention can treat or prevent tumors and has application prospects.
Inventors:
WANG ZHONGMIN (CN)
LI BAIYONG (CN)
XIA YU (CN)
LI BAIYONG (CN)
XIA YU (CN)
Application Number:
PCT/CN2023/097757
Publication Date:
March 14, 2024
Filing Date:
June 01, 2023
Export Citation:
Assignee:
AKESO BIOPHARMA INC (CN)
AKESO PHARMACEUTICALS INC (CN)
AKESO PHARMACEUTICALS INC (CN)
International Classes:
C07K16/46; A61K39/395; A61P35/00; A61P35/02; C12N15/13
Domestic Patent References:
| WO2021133653A1 | 2021-07-01 |
Foreign References:
| CN112300286A | 2021-02-02 | |||
| CN112830972A | 2021-05-25 | |||
| CN106967172A | 2017-07-21 | |||
| CN107151269A | 2017-09-12 | |||
| CN109053895A | 2018-12-21 | |||
| CN112300280A | 2021-02-02 | |||
| CN112638403A | 2021-04-09 | |||
| US4816567A | 1989-03-28 | |||
| CN112300286A | 2021-02-02 | |||
| CN112830972A | 2021-05-25 | |||
| CN106967172A | 2017-07-21 | |||
| CN1259962A | 2000-07-12 |
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CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
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JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
ACIERNO ET AL.: "Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies", J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 146, XP022310713, DOI: 10.1016/j.jmb.2007.09.005
HAMANISHI ET AL., PROC. NATL. ACAD SCI. USA, vol. 104, 2007, pages 3360 - 5
HOMET M. B.PARISI G. ET AL., SEMIN ONCOL., vol. 42, no. 3, 2015, pages 466 - 473
HELD SAHEINE A ET AL., CURR CANCER DRUG TARGETS., vol. 13, no. 7, 2013, pages 768 - 74
CHAVEZ, A.R. ET AL., ANN. N. Y. ACAD SCI., vol. 1182, 2009, pages 14 - 27
DAFNE MULLERKONTERMANN R E., BIODRUGS, vol. 24, no. 2, 2010, pages 89 - 98
COLOMA MJMORRISON SL., NAT BIOTECHNOL., vol. 15, 1997, pages 159 - 163
MILLER BRDEMAREST SJ ET AL., PROTEIN ENG DES SEL, vol. 23, 2010, pages 549 - 57
FITZGERALD JLUGOVSKOY A., MABS, vol. 3, 2011, pages 299 - 309
MA LI, CHINESE JOURNAL OF BIRTH HEALTH AND HEREDITY, vol. 24, no. 5, 2016, pages 146 - 148
ROSKOSKI R JR. ET AL., CRIT REV ONCOL HEMATOL, vol. 62, no. 3, 2007, pages 179 - 213
TAKAHASHI T ET AL., ONCOGENE, vol. 18, no. 13, 1999, pages 2221 - 2230
DONG HONGCHAO ET AL., JOURNAL OF MODERN ONCOLOGY, vol. 22, no. 9, September 2014 (2014-09-01), pages 2231 - 3
BARETTI M ET AL., PHARMACOL THER., vol. 189, 2018, pages 45 - 62
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
"NCBI", Database accession no. 3791
"GenBank", Database accession no. NP _001165097.1
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
ACIERNO ET AL.: "Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies", J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 146, XP022310713, DOI: 10.1016/j.jmb.2007.09.005
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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