Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2010/029996
Kind Code:
A1
Abstract:
A pharmaceutical composition containing a pentadienamide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof and (b) an analgesic.
(In the formula, R1 represents a substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R2 represents a substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group or the like; R3 represents a hydrogen atom or the like; R4 represents a substituted or unsubstituted lower alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted alicyclic heterocyclic group or the like; and R5, R6 and R7 each represents a hydrogen atom or the like.)
Inventors:
KATO YOSHIMITSU
SHIRAKURA SHIRO
SHIRAKURA SHIRO
Application Number:
PCT/JP2009/065912
Publication Date:
March 18, 2010
Filing Date:
September 11, 2009
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
KATO YOSHIMITSU
SHIRAKURA SHIRO
KATO YOSHIMITSU
SHIRAKURA SHIRO
International Classes:
A61K31/03; A61K31/045; A61K31/075; A61K31/085; A61K31/135; A61K31/136; A61K31/137; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/192; A61K31/195; A61K31/197; A61K31/343; A61K31/353; A61K31/357; A61K31/40; A61K31/4035; A61K31/404; A61K31/415; A61K31/4155; A61K31/416; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/42; A61K31/4245; A61K31/426; A61K31/428; A61K31/433; A61K31/4365; A61K31/44; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4468; A61K31/47; A61K31/4704; A61K31/4709; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/4965; A61K31/498; A61K31/4985; A61K31/502; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/536; A61K31/5375; A61K31/5377; A61K31/538; A61K31/54; A61K31/55; A61K31/553; A61K45/00; A61P25/04; A61P29/00; A61P43/00; C07D215/38
Domestic Patent References:
| WO2008007780A1 | 2008-01-17 | |||
| WO2008096755A1 | 2008-08-14 | |||
| WO2005044786A1 | 2005-05-19 |
Foreign References:
| JP2007523143A | 2007-08-16 | |||
| JP2006511535A | 2006-04-06 | |||
| JP2006515847A | 2006-06-08 |
Other References:
ACS, GEZA ET AL.: "Trifluoperazine Modulates [3H] Resiniferatoxin Binding by Human and Rat Vanilloid (Capsaicin) Receptors and Affects 45Ca Uptake by Adult Rat Dorsal Root Ganglion Neurones", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 274, no. 3, 1995, pages 1090 - 1098
VETTER, IRINA ET AL.: "Rapid, Opioid-sensitive Mechanisms Involved in Transient Receptor Potential Vaniloid 1 Sensitization", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 28, 11 July 2008 (2008-07-11), pages 19540 - 19550
WALKER, KATHARINE M ET AL.: "The VR1 antagonist Capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 304, no. 1, 2003, pages 56 - 62
JU MIZUNO ET AL.: "Q&A Mansei Totsu ni Taisuru Kakushu Koutsuyaku no Chiryo ni Tsuite", PAIN CLINIC, vol. 26, no. 4, April 2005 (2005-04-01), pages 576 - 577
VETTER, IRINA ET AL.: "Rapid, Opioid-sensitive Mechanisms Involved in Transient Receptor Potential Vaniloid 1 Sensitization", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 283, no. 28, 11 July 2008 (2008-07-11), pages 19540 - 19550
WALKER, KATHARINE M ET AL.: "The VR1 antagonist Capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 304, no. 1, 2003, pages 56 - 62
JU MIZUNO ET AL.: "Q&A
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