Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2015/170757
Kind Code:
A1
Abstract:
Provided is a carrier that can achieve both the stability of a biologic drug in the blood and the release of the drug in target cells. A pharmaceutical composition according to the present invention includes an α polymer unit that has a hydrophilic polymer chain segment and a cationic polymer chain segment, a β polymer unit that has a hydrophilic polymer chain segment and a cationic polymer chain segment, and a drug. The α and β polymer units form micelles that have a radial arrangement wherein the cationic polymer chain segments are on the inside and the hydrophilic polymer chain segments are on the outside. The drug is contained inside the micelles. A side chain of the cationic polymer chain segment of the α polymer unit has a phenylboronic acid group, and a side chain of the cationic polymer chain segment of the β polymer unit has a phenylboronic acid-binding site. The phenylboronic acid group and the phenylboronic acid-binding site form a cross-linked structure that can be lysed under acidic conditions or in the presence of a substance that is capable of competitive binding.
Inventors:
KATAOKA KAZUNORI (JP)
ISHII TAKEHIKO (JP)
NAITO MITSURU (JP)
YOSHINAGA NAOTO (JP)
ENDO TAISUKE (JP)
ISHII TAKEHIKO (JP)
NAITO MITSURU (JP)
YOSHINAGA NAOTO (JP)
ENDO TAISUKE (JP)
Application Number:
PCT/JP2015/063363
Publication Date:
November 12, 2015
Filing Date:
May 08, 2015
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K9/107; A61K31/7105; A61K31/711; A61K47/34; A61K48/00
Foreign References:
| JP2012500208A | 2012-01-05 |
Other References:
NAOTO YOSHINAGA ET AL.: "Phenylboronic Acid o Kobunshi Micelle Core no Kakyozai to shite Mochiiru Saibonai Kankyo Oto-gata Kakusan Delivery System no Soshutsu", POLYMER PREPRINTS, vol. 63, no. 1, 9 May 2014 (2014-05-09), Japan, pages 3539 - 3540, XP008185232
DESHAYES ET AL.: "Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 41, 12 September 2013 (2013-09-12), pages 15501 - 15507, XP055237106
CHENG ET AL.: "Phenylboronic acid-containing block copolymers: synthesis, self-assembly,and application for intracellular delivery of proteins", NEW JOURNAL OF CHEMISTRY, vol. 36, no. 6, 2012, pages 1413 - 1421, XP055237110
See also references of EP 3141243A4
DESHAYES ET AL.: "Phenylboronic Acid-Installed Polymeric Micelles for Targeting Sialylated Epitopes in Solid Tumors", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 41, 12 September 2013 (2013-09-12), pages 15501 - 15507, XP055237106
CHENG ET AL.: "Phenylboronic acid-containing block copolymers: synthesis, self-assembly,and application for intracellular delivery of proteins", NEW JOURNAL OF CHEMISTRY, vol. 36, no. 6, 2012, pages 1413 - 1421, XP055237110
See also references of EP 3141243A4
Attorney, Agent or Firm:
MOMII, Takafumi (JP)
Takafumi Momii (JP)
Takafumi Momii (JP)
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