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Document Type and Number:
WIPO Patent Application WO/2016/006577
Kind Code:
A pharmaceutical composition for use in the treatment or prevention of disorders associated with ischemia, said composition comprising a mitochondrial damage-inhibiting agent, an anti-inflammatory agent, and biocompatible particles encapsulating either or both of the mitochondrial damage-inhibiting agent and the anti-inflammatory agent. The biocompatible particle may include a poly(lactide-glycolide) copolymer having a number average particle diameter of 2.5 to 1000 nm, or a polyethylene glycol-modified material derived therefrom.

EGASHIRA Kensuke (9th Floor, Hakataza Nishiginsaikaihatsu Building 2-1, Shimokawabatamachi, Hakata-ku, Fukuoka-sh, Fukuoka 27, 〒8120027, JP)
Application Number:
Publication Date:
January 14, 2016
Filing Date:
July 06, 2015
Export Citation:
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KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (6-10-1, Hakozaki Higashi-ku Fukuoka-sh, Fukuoka 81, 〒8128581, JP)
International Classes:
A61K45/06; A61K9/14; A61K31/4184; A61K31/4439; A61K31/47; A61K38/00; A61K47/34; A61P9/10; A61P43/00
Domestic Patent References:
Foreign References:
Other References:
NAGAOKA, K. ET AL.: "A new therapeutic modality for ischemia-reperfusion injury: Nanoparticle- mediated delivery of pitavastatin reduces ischemia-reperfusion injury and improves left ventricular function in rats", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 65, no. Suppl. 1, 2013, pages S71, XP008185593
IKEDA, G. ET AL.: "Nanoparticle-mediated selective delivery into lesions of myocardial ischemia-reperfusion injury enhances cardioprotection by cyclosporine a in mice", CIRCULATION, vol. 126, no. 21, Suppl. 1, 2012, XP055397850
IKEDA, G. ET AL.: "Nanoparticle-mediated targeting of Cyclosporine A to mitochondria in reperfused myocardium enhances cardioprotection from ischemia-reperfusion injury", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 65, no. Suppl. 1, 2013, pages S70, XP008185579
INMAN S.R. ET AL.: "Simvastatin attenuates renal ischemia/reperfusion injury in rats administered cyclosporine A", THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES, vol. 326, no. 3, 2003, pages 117 - 21, XP055381065
NAGAOKA, K. ET AL.: "A new therapeutic modality for acute myocardial infarction: nanoparticle- mediated delivery of pitavastatin induces cardioprotection from ischemia-reperfusion injury via activation of pi3k/akt pathway and anti-inflammation in a rat model", PLOS ONE, vol. 10, no. 7, July 2015 (2015-07-01), pages 1 - 23, XP055381068
ISHIKITA, A. ET AL.: "Nanoparticle-mediated targeting of a mitochondria division inhibitor, mdivi-1, to the mitochondria induces cardioprotection from ischemia-reperfusion injury", CIRCULATION, vol. 130, no. Suppl. 2, November 2014 (2014-11-01), XP055397845
IKEDA, G. ET AL.: "Nanoparticle-mediated targeting of cyclosporine a to the mitochondria of reperfused myocardium enhances cardioprotection against ischemia-reperfusion injury in preclinical models", EUROPEAN HEART JOURNAL, vol. 35, no. Suppl. 1, September 2014 (2014-09-01), pages 6, XP008185525
See also references of EP 3170512A4
Attorney, Agent or Firm:
KIMURA Mitsuru (2nd Floor, Kyohan Building 7, Kandanishiki-cho 2-chome, Chiyoda-k, Tokyo 54, 〒1010054, JP)
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