Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2017/222040
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition which can be administered to a human body safely and is effective for the treatment of PolyQ diseases. The present invention provides: a pharmaceutical composition which contains arginine, a physiologically acceptable salt of arginine or a solvate of arginine or the physiologically acceptable salt as an active ingredient and can be used for the treatment or prevention of a PolyQ disease; and the pharmaceutical composition described above, wherein the PolyQ disease is Huntington's disease, hereditary spinocerebellar ataxia, dentatorubropallidoluysial atrophy or spinal and bulbar muscular atrophy.
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Inventors:
NAGAI YOSHITAKA (JP)
POPIEL HELENA AKIKO (JP)
MINAKAWA EIKO (JP)
POPIEL HELENA AKIKO (JP)
MINAKAWA EIKO (JP)
Application Number:
PCT/JP2017/023162
Publication Date:
December 28, 2017
Filing Date:
June 23, 2017
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
International Classes:
A61P21/02; A61K31/198; A61P25/00; A61P25/14
Domestic Patent References:
| WO2015061856A1 | 2015-05-07 |
Other References:
DECKEL A. W. ET AL.: "Dietary arginine alters time of symptom onset in Huntington's desease transgenic mice", BRAIN RESEARCH, vol. 875, 2000, pages 187 - 195, XP055446847
NAKAYAMA IZUMI ET AL.: "Inhibition of polyglutamine aggregation by arginine and its effect on a polyglutamine disease mouse", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 45, no. 2-3, 25 August 2006 (2006-08-25), pages 455, XP009514221
See also references of EP 3476391A4
NAKAYAMA IZUMI ET AL.: "Inhibition of polyglutamine aggregation by arginine and its effect on a polyglutamine disease mouse", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 45, no. 2-3, 25 August 2006 (2006-08-25), pages 455, XP009514221
See also references of EP 3476391A4
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
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