Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/215658
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound that binds to PGRMC1 and inhibits the function of PGRMC1. The present invention provides a PGRMC1 function inhibitor comprising glycyrrhizin, a glycyrrhizin derivative, or a salt thereof.
Inventors:
KABE YASUAKI (JP)
TSUGAWA HITOSHI (JP)
SUEMATSU MAKOTO (JP)
YOSHIKAWA NOBUJI (JP)
TSUGAWA HITOSHI (JP)
SUEMATSU MAKOTO (JP)
YOSHIKAWA NOBUJI (JP)
Application Number:
PCT/JP2022/016800
Publication Date:
October 13, 2022
Filing Date:
March 31, 2022
Export Citation:
Assignee:
UNIV KEIO (JP)
COKEY SYSTEMS CO LTD (JP)
COKEY SYSTEMS CO LTD (JP)
International Classes:
A61K31/704; A61P1/16; A61P3/04; A61P35/00; A61P37/08; A61P43/00
Foreign References:
| JPH0272187A | 1990-03-12 | |||
| JP2006219380A | 2006-08-24 | |||
| JP2014094917A | 2014-05-22 |
Other References:
加部泰明他. 2. 天然甘味料グリチルリチンの新規受容体の探索と生理機能の解明. 機能性食品と薬理栄養. 2014, vol. 8, no. 5, p. 394, (Journal of Japanese Society for Medical Use of Functional Foods), non-official translation (KABE, Yasuaki et al. 2. Search for Novel Receptors of Natural Sweetener Glycyrrhizin, Elucidation of Physiological Functions.)
SCHMID CHRISTIAN, DAWID CORINNA, PETERS VERENA, HOFMANN THOMAS: "Saponins from European Licorice Roots ( Glycyrrhiza glabra )", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 81, no. 8, 24 August 2018 (2018-08-24), US , pages 1734 - 1744, XP055975171, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.8b00022
KABE YASUAKI, HANDA HIROSHI, SUEMATSU MAKOTO: "Function and structural regulation of the carbon monoxide (CO))responsive membrane protein PGRMC1", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 63, no. 1, 11 April 2018 (2018-04-11), pages 12 - 17, XP055975174, DOI: 10.3164/jcbn.17-132
FURUHATA RYOGO, KABE YASUAKI, KANAI AYAKA, SUGIURA YUKI, TSUGAWA HITOSHI, SUGIYAMA EIJI, HIRAI MIWA, YAMAMOTO TAKEHIRO, KOIKE IKKO: "Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes", COMMUNICATIONS BIOLOGY, vol. 3, no. 1, 1 December 2020 (2020-12-01), XP055975177, DOI: 10.1038/s42003-020-01202-x
KABE YASUAKI, KOIKE IKKO, YAMAMOTO TATSUYA, HIRAI MIWA, KANAI AYAKA, FURUHATA RYOGO, TSUGAWA HITOSHI, HARADA ERISA, SUGASE KENJI, : "Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1", CANCERS, vol. 13, no. 13, pages 3265, XP055975178, DOI: 10.3390/cancers13133265
SCHMID CHRISTIAN, DAWID CORINNA, PETERS VERENA, HOFMANN THOMAS: "Saponins from European Licorice Roots ( Glycyrrhiza glabra )", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 81, no. 8, 24 August 2018 (2018-08-24), US , pages 1734 - 1744, XP055975171, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.8b00022
KABE YASUAKI, HANDA HIROSHI, SUEMATSU MAKOTO: "Function and structural regulation of the carbon monoxide (CO))responsive membrane protein PGRMC1", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 63, no. 1, 11 April 2018 (2018-04-11), pages 12 - 17, XP055975174, DOI: 10.3164/jcbn.17-132
FURUHATA RYOGO, KABE YASUAKI, KANAI AYAKA, SUGIURA YUKI, TSUGAWA HITOSHI, SUGIYAMA EIJI, HIRAI MIWA, YAMAMOTO TAKEHIRO, KOIKE IKKO: "Progesterone receptor membrane associated component 1 enhances obesity progression in mice by facilitating lipid accumulation in adipocytes", COMMUNICATIONS BIOLOGY, vol. 3, no. 1, 1 December 2020 (2020-12-01), XP055975177, DOI: 10.1038/s42003-020-01202-x
KABE YASUAKI, KOIKE IKKO, YAMAMOTO TATSUYA, HIRAI MIWA, KANAI AYAKA, FURUHATA RYOGO, TSUGAWA HITOSHI, HARADA ERISA, SUGASE KENJI, : "Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1", CANCERS, vol. 13, no. 13, pages 3265, XP055975178, DOI: 10.3390/cancers13133265
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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