Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/286823
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition which contains: an LAT1 inhibitor, such as 5-phenyl-5-[4-(trifluoromethyl)phenoxy]pentan-1-amine or a 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid or a pharmaceutically acceptable salt thereof; and an mTOR inhibitor or a serotonin inhibitor.
Inventors:
HIKITA HAYATO (JP)
TAKEHARA TETSUO (JP)
FUKUMOTO KENJI (JP)
TAKEHARA TETSUO (JP)
FUKUMOTO KENJI (JP)
Application Number:
PCT/JP2022/027652
Publication Date:
January 19, 2023
Filing Date:
July 14, 2022
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K31/138; A61K31/135; A61K31/436; A61K45/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2014112646A1 | 2014-07-24 | |||
| WO2015173970A1 | 2015-11-19 |
Other References:
CHUN SUNG KIM, SEON-HO CHO,HONG SUNG CHUN,SOOK-YOUNG LEE, HITOSHI ENDOU,YOSHIKATSU KANAI , DO KYUNG KIM: "BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells", BIOL. PHARM. BULL, vol. 31, no. 6, 30 June 2008 (2008-06-30), pages 1096 - 10100, XP055634843, DOI: 10.1248/bpb.31.1096
SAPONARA ENRICA, VISENTIN MICHELE, BASCHIERI FRANCESCO, SELEZNIK GITTA, MARTINELLI PAOLA, ESPOSITO IRENE, BUSCHMANN JOHANNA, CHEN : "Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas : Serotonin promotes ADM formation", THE JOURNAL OF PATHOLOGY, LONGMAN, HOBOKEN, USA, vol. 246, no. 3, 1 November 2018 (2018-11-01), Hoboken, USA, pages 352 - 365, XP055875155, ISSN: 0022-3417, DOI: 10.1002/path.5147
SAPONARA ENRICA, VISENTIN MICHELE, BASCHIERI FRANCESCO, SELEZNIK GITTA, MARTINELLI PAOLA, ESPOSITO IRENE, BUSCHMANN JOHANNA, CHEN : "Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas : Serotonin promotes ADM formation", THE JOURNAL OF PATHOLOGY, LONGMAN, HOBOKEN, USA, vol. 246, no. 3, 1 November 2018 (2018-11-01), Hoboken, USA, pages 352 - 365, XP055875155, ISSN: 0022-3417, DOI: 10.1002/path.5147
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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