Title:
PHARMACEUTICAL COMPOSITIONS AFFECTING MITOCHONDRIAL REDOX STATE AND METHODS OF TREATMENT
Document Type and Number:
WIPO Patent Application WO/2016/191458
Kind Code:
A3
Abstract:
Provided herein are methods for treating diseases, disorders and/or medical conditions with pharmaceutical compositions consisting of an association of active principles that affect mitochondrial redox state. Also provided herein are methods for the preparation of said pharmaceutical compositions for use in the methods of the embodiments of the present invention. Also provided herein are novel dosing strategies for administering the pharmaceutical compositions.
Inventors:
SHEEHAN JAMES (US)
Application Number:
PCT/US2016/034032
Publication Date:
May 26, 2017
Filing Date:
May 25, 2016
Export Citation:
Assignee:
JOYCE BIOTECH CORP (US)
International Classes:
A61K31/56; A61K31/155; C07C279/26
Foreign References:
| US20050215533A1 | 2005-09-29 | |||
| US20140128352A1 | 2014-05-08 | |||
| US20120088744A1 | 2012-04-12 |
Other References:
ROUSSEL.: "Kinetics and control of oxidative phosphorylation in rat liver mitochondria after dexamethasone treatment.", BIOCHEM. J., vol. 382, no. 2, 2004, pages 491 - 499, XP055383226
SHACKELFORD ET AL.: "LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin.", CANCER CELL, vol. 23, 2013, pages 143 - 158, XP028976809
DROUET ET AL.: "Metyrapone effects on systemic and cerebral energy metabolism.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 682, 2012, pages 92 - 98, XP028476263
SHACKELFORD ET AL.: "LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin.", CANCER CELL, vol. 23, 2013, pages 143 - 158, XP028976809
DROUET ET AL.: "Metyrapone effects on systemic and cerebral energy metabolism.", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 682, 2012, pages 92 - 98, XP028476263
Attorney, Agent or Firm:
KOO, Mark, T. (US)
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