Title:
PHARMACEUTICAL COMPOSITIONS COMPRISING DEUTERIUM-ENRICHED PERILLYL ALCOHOL, ISO-PERILLYL ALCOHOL AND DERIVATIVES THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/119304
Kind Code:
A3
Abstract:
The present invention, provides for a deuterium-enriched monoterpene or sesquiterpene such as perillyl alcohol, or a deuterium-enriched isomer or analog of monoterpenes or sesquiterpenes, such as isoperillyl alcohol. The present invention also provides for a deuterium-enriched derivative of a monoterpene or sesquiterpene, such as a perillyl alcohol carbamate, or a deuterium-enriched derivative of an isomer or analog of a monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The deuterium-enriched derivative may be perillyl alcohol or isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a deuterium-enriched compound.
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Inventors:
CHEN THOMAS (US)
LEVIN DANIEL (US)
PUPALLI SATISH (US)
LEVIN DANIEL (US)
PUPALLI SATISH (US)
Application Number:
PCT/US2012/066379
Publication Date:
October 03, 2013
Filing Date:
November 21, 2012
Export Citation:
Assignee:
NEONC TECHNOLOGIES INC (US)
International Classes:
C07C35/18
Domestic Patent References:
| WO2012027693A2 | 2012-03-01 |
Foreign References:
| US20100168228A1 | 2010-07-01 | |||
| US20060014732A1 | 2006-01-19 |
Other References:
CHEN ET AL.: "Synthesis of Deuterium Labeled Perillyl Alcohol and Dual C-13 and Deuterium Labeled Perillic Acid, Major Metabolites of d-Limonene.", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. XXXIX, no. 5, 1997, XP055149706
See also references of EP 2782894A4
See also references of EP 2782894A4
Attorney, Agent or Firm:
DAVITZ, Michael, A. (Veltrop & Harkrider LLP114 West 47th Stree, New York NY, US)
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