Title:
PHARMACEUTICAL COMPOSITIONS OF A NON-ENTERIC COATED PROTON PUMP INHIBITOR WITH A CARBONATE SALT AND BICARBONATE SALT COMBINATION
Document Type and Number:
WIPO Patent Application WO2002053097
Kind Code:
A3
Abstract:
A method for treating gastric acid disorders with a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal; and a pharmaceutical composition of a non-enteric coated proton pump inhibitor in a pharmaceutically acceptable carrier including a bicarbonate salt of a Group IA metal and a carbonate salt of a Group IA metal are disclosed. A presently preferred proton pump inhibitor is lansoprazole, a presently preferred bicarbonate salt is sodium bicarbonate, and a presently preferred carbonate salt is sodium carbonate. The composition is a fast-acting formulation which reduces the undesirable belching associated with proton pump inhibitor formulations that contain high doses of sodium bicarbonate.
Inventors:
TANEJA RAJNEESH
GUPTA PRAMOD
GUPTA PRAMOD
Application Number:
PCT/US2001/048320
Publication Date:
January 30, 2003
Filing Date:
December 12, 2001
Export Citation:
Assignee:
TAP PHARMACEUTICAL PROD INC (US)
International Classes:
C07D401/12; A61K9/00; A61K9/16; A61K31/4439; A61K45/00; A61K47/02; A61P1/04; A61P43/00; (IPC1-7): A61K31/445; A61K33/00
Foreign References:
| US5750104A | 1998-05-12 | |||
| US5840737A | 1998-11-24 |
Other References:
DATABASE WPIDS [online] (COLUMBUS, OH, USA); COOK: "Composition used for treating gastric and duodenal ulcers contains benzimidazole compound and e.g. sodium hydroxide", XP002951122, accession no. STN Database accession no. 2001-320522
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