PHARMACEUTICAL COMPOSITIONS FOR THE ORAL DELIVERY OF PHARMACOLOGICALLY ACTIVE AGENTS

Title:

PHARMACEUTICAL COMPOSITIONS FOR THE ORAL DELIVERY OF PHARMACOLOGICALLY ACTIVE AGENTS

Document Type and Number:

WIPO Patent Application WO2002045754

Kind Code:

A3

Abstract:

Solid pharmaceutical compositions suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions provide excellent oral bioavailability of pharmacologically active agents, particularly calcitonin.

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Inventors:

AULT JOSEPH M (US)
AZRIA MOISE (CH)
BATEMAN SIMON DAVID (US)
SIKORA JOSEPH (US)
SPARTA GREGORY (US)
YANG REBECCA FAI-YING (US)
XIAO JIE (US)

Application Number:

PCT/EP2001/014294

Publication Date:

January 03, 2003

Filing Date:

December 05, 2001

Export Citation:

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Assignee:

NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
AULT JOSEPH M (US)
AZRIA MOISE (CH)
BATEMAN SIMON DAVID (US)
SIKORA JOSEPH (US)
SPARTA GREGORY (US)
YANG REBECCA FAI-YING (US)
XIAO JIE (US)

International Classes:

A61K9/20; A61K38/22; A61K47/12; A61K47/16; A61K47/18; A61K47/32; A61K47/38; A61P3/14; A61P19/08; A61P19/10; (IPC1-7): A61K9/20; A61K47/34; A61K38/23; A61K35/60; A61P19/08; A61P19/10; A61K47/38; A61K47/18

Domestic Patent References:

WO2000057857A1

2000-10-05

Foreign References:

US5773647A	1998-06-30
US5866536A	1999-02-02
US5002771A	1991-03-26
US5972381A	1999-10-26
GB2295966A	1996-06-19

Other References:

DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 2001 (2001-07-01), LEONE-BAY ANDREA ET AL: "Oral delivery of biologically active parathyroid hormone.", XP002214663, Database accession no. PREV200100449260

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