Title:
PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF DIABETIC NEPHROPATHY
Document Type and Number:
WIPO Patent Application WO/2002/002553
Kind Code:
A1
Abstract:
Pharmaceutical compositions for the treatment of overt and/or early diabetic nephropathy, containing as the active ingredient (Z)-4'-{4,4-difluoro-5-[2-oxo-2-(4-piperidino- piperidino)ethylidene]-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl}-2-methyl-3-furanilide or pharmaceutically acceptable salts thereof.
Inventors:
TAHARA ATSUO (JP)
SUZUKI TAKESHI (JP)
YATSU TAKEYUKI (JP)
TOMURA YUICHI (JP)
TSUKADA JUNKO (JP)
SUZUKI TAKESHI (JP)
YATSU TAKEYUKI (JP)
TOMURA YUICHI (JP)
TSUKADA JUNKO (JP)
Application Number:
PCT/JP2001/005743
Publication Date:
January 10, 2002
Filing Date:
July 03, 2001
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
TAHARA ATSUO (JP)
SUZUKI TAKESHI (JP)
YATSU TAKEYUKI (JP)
TOMURA YUICHI (JP)
TSUKADA JUNKO (JP)
TAHARA ATSUO (JP)
SUZUKI TAKESHI (JP)
YATSU TAKEYUKI (JP)
TOMURA YUICHI (JP)
TSUKADA JUNKO (JP)
International Classes:
A61K31/55; A61P3/06; A61P13/12; C07D405/14; (IPC1-7): C07D405/14; A61K31/55; A61P3/06; A61P13/12
Foreign References:
| EP0716083A1 | 1996-06-12 | |||
| JP2000063363A | 2000-02-29 |
Other References:
YAMANOUCHI PHARMACEUTICAL CO. LTD., JOURNAL OF TECHNICAL DISCLOSURE (HATSUMEI KYOKAI KOUKAI GIHO), vol. 097, no. 9952, 15 December 1997 (1997-12-15), HATSUMEI KYOUKAI, pages 1 - 2
NISHIKAWA TESUO ET AL.: "Short-term clinical trial of 1- (1-(4-(3-acetylaminopropoxy)-benzoyl)-4-piperidyl)-3,4-dihydro-2 (1H)-quinolinone in patients with diabetic nephropathy", ARZNEIM-FORSCH/DRUGRES, vol. 46, no. 9, 1996, pages 875 - 878, XP002945529
BARDOUX PASCALE ET AL.: "Vasopressin contributes to hyperfiltration, albuminuria and renal hypertrophy in diabetes mellitus: study in vasopressin-deficient brattleboro rats", PROC. NATL. ACAD. SCI. USA, vol. 96, no. 18, 1999, pages 10397 - 10402, XP002945530
NISHIKAWA TESUO ET AL.: "Short-term clinical trial of 1- (1-(4-(3-acetylaminopropoxy)-benzoyl)-4-piperidyl)-3,4-dihydro-2 (1H)-quinolinone in patients with diabetic nephropathy", ARZNEIM-FORSCH/DRUGRES, vol. 46, no. 9, 1996, pages 875 - 878, XP002945529
BARDOUX PASCALE ET AL.: "Vasopressin contributes to hyperfiltration, albuminuria and renal hypertrophy in diabetes mellitus: study in vasopressin-deficient brattleboro rats", PROC. NATL. ACAD. SCI. USA, vol. 96, no. 18, 1999, pages 10397 - 10402, XP002945530
Attorney, Agent or Firm:
Nagai, Shozo c/o Yamanouchi Pharmaceutical Co. (Ltd. Patent Department 17-1 Hasune 3-chome Itabashi-ku, Tokyo, JP)
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