PHARMACEUTICAL COMPOSITIONS WHICH INHIBIT FKBP52-MEDIATED REGULATION OF ANDROGEN RECEPTOR FUNCTION AND METHODS OF USING SAME

Title:

PHARMACEUTICAL COMPOSITIONS WHICH INHIBIT FKBP52-MEDIATED REGULATION OF ANDROGEN RECEPTOR FUNCTION AND METHODS OF USING SAME

Document Type and Number:

WIPO Patent Application WO/2011/034834

Kind Code:

A3

Abstract:

Pharmaceutical compositions that bind to a predicted FK506 Binding Protein 52 (FKBP52) interaction surface on the androgen receptor hormone binding domain, otherwise known as FKBP52 Targeting Agents (FTAs) are provided. These compositions of the present invention are found to specifically recognize the FKBP52 regulatory surface on the androgen receptor and inhibit FKBP52 from functionally interacting with the androgen receptor. Compositions comprising the pharmaceutical composition, as well as methods of use, treatment and screening are also provided.

More Like This:

JP6513729	Allogeneic graft
WO/2023/228095	DOSAGE REGIMEN OF AN ANTI-CDH6 ANTIBODY-DRUG CONJUGATE
JP2518739	INDUSTRIAL APPLICABILITY: Tumor-suppressing satuccalide inclusions

Inventors:

NECKERS LEONARD M (US)
COX MARC B (US)
TREPEL JANE B (US)
KIM YEONG SANG (US)
IWAI AKI (US)
NING YANGMIN (US)
MENESES DE LEON JOHANNY (US)
BALSIGER HEATHER A (US)
FLETTERICK ROBERT (US)

Application Number:

PCT/US2010/048705

Publication Date:

May 12, 2011

Filing Date:

September 14, 2010

Export Citation:

Click for automatic bibliography generation Help

Assignee:

US HEALTH (US)
UNIV CALIFORNIA (US)
UNIV TEXAS AT EL PASO (US)
NECKERS LEONARD M (US)
COX MARC B (US)
TREPEL JANE B (US)
KIM YEONG SANG (US)
IWAI AKI (US)
NING YANGMIN (US)
MENESES DE LEON JOHANNY (US)
BALSIGER HEATHER A (US)
FLETTERICK ROBERT (US)

International Classes:

A61P35/00; A61K31/167; A61K31/192; A61K31/4355; A61P3/10; A61P5/28

Domestic Patent References:

WO2004032716A2

2004-04-22

Foreign References:

US20070099970A1

2007-05-03

Other References: