Title:
PHARMACEUTICAL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/151727
Kind Code:
A1
Abstract:
Disclosed are a pharmaceutical compound and a preparation method therefor and a use thereof. The pharmaceutical compound comprises an active ingredient and a carrier; the carrier is albumin, the active ingredient is loaded on the carrier, and the active ingredient is a platinum-based drug. Compared with free platinum-based drugs, the pharmaceutical compound can significantly extend the in vivo half-life period of the platinum-based drugs, improve the in vivo tissue distribution of the platinum-based drug, improve the tissue selectivity of the platinum-based drug, reduce systemic toxicity and the damage of the platinum-based drug to normal tissues, and improve the therapeutic effect.
Inventors:
QIAN FENG (CN)
YE JUNXIAO (CN)
KONG CHAO (CN)
YE JUNXIAO (CN)
KONG CHAO (CN)
Application Number:
PCT/CN2020/073666
Publication Date:
July 30, 2020
Filing Date:
January 22, 2020
Export Citation:
Assignee:
NOVAGENESIS THERAPEUTIX HK LTD (CN)
International Classes:
A61K47/42; A61K31/282; A61P35/00
Foreign References:
| CN104606127A | 2015-05-13 | |||
| CN101708337A | 2010-05-19 | |||
| CN105228612A | 2016-01-06 | |||
| CN109730998A | 2019-05-10 |
Other References:
SAIKAT DAS, LAVANYA JAGAN, RAJESH ISIAH, B. RAJESH, SELVAMANI BACKIANATHAN, J. SUBHASHINI: "Nanotechnology in Oncology: Characterization and in Vitro Release Kinetics of Cisplatin-loaded Albumin Nanoparticles: Implications in Anticancer Drug Delivery", INDIAN JOURNAL OF PHARMACOLOGY, vol. 43, no. 4, 31 August 2011 (2011-08-31), pages 409 - 413, XP009522377, ISSN: 0253-7613, DOI: 10.4103/0253-7613.83111
ZHU, HAO; JIANG, XUETAO; XU, FENGHUA: "Preparation of Carboplatin-loaded Albumin Microsphere and Its Properties in Vitro", CHINESE PHARMACEUTICAL JOURNAL, vol. 33, no. 2, 28 February 1998 (1998-02-28), pages 91 - 94, XP009522379, ISSN: 1001-2494
ZHU, HAO; JIANG, XUETAO; XU, FENGHUA: "Preparation of Carboplatin-loaded Albumin Microsphere and Its Properties in Vitro", CHINESE PHARMACEUTICAL JOURNAL, vol. 33, no. 2, 28 February 1998 (1998-02-28), pages 91 - 94, XP009522379, ISSN: 1001-2494
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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