PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Title:

PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Document Type and Number:

WIPO Patent Application WO2006074223

Kind Code:

A3

Abstract:

Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Inventors:

CAI SUI XIONG (US)
ANDERSON MARK B (US)
WILLARDSEN ADAM (US)
JIANG SONGCHUN (US)
HALTER ROBERT J (US)
SLADE RACHEL (US)
KLIMOVA YEVGENIYA (US)

Application Number:

PCT/US2006/000176

Publication Date:

August 31, 2006

Filing Date:

January 03, 2006

Export Citation:

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Assignee:

MYRIAD GENETICS INC (US)
CYTOVIA INC (US)
CAI SUI XIONG (US)
ANDERSON MARK B (US)
WILLARDSEN ADAM (US)
JIANG SONGCHUN (US)
HALTER ROBERT J (US)
SLADE RACHEL (US)
KLIMOVA YEVGENIYA (US)

International Classes:

C07D253/08; A61K31/472; A61K31/502; A61K31/53; A61P35/00; C07D217/22; C07D237/28; C07D237/30

Foreign References:

US6589951B1	2003-07-08
US6498159B1	2002-12-24
US6492360B1	2002-12-10
US6514971B1	2003-02-04
US6235752B1	2001-05-22
US20040176603A1	2004-09-09

Other References: