Title:
BEVERAGE/FOOD AND PHARMACEUTICAL COMPRISING LOQUAT LEAF EXTRACT
Document Type and Number:
WIPO Patent Application WO/2007/001080
Kind Code:
A1
Abstract:
A beverage/food or pharmaceutical comprising a loquat leaf or an extract or purified product from a loquat leaf as an active ingredient and has one or more effects selected from the group consisting of an antihyperlipemic effect, an antihypertensive effect, an inhibitory effect on the proliferation of a cancer cell, an effect of inducing the apoptosis of a cancer cell, an effect of producing an active oxygen species, an antihyperglycemic effect and an anti-oxidant effect.
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Inventors:
SAKATA YUSUKE (JP)
FUJII MAKOTO (JP)
NAKANO TAKAYUKI (JP)
KO NORIOKI (JP)
HASHIMOTO FUMIO (JP)
FUJII MAKOTO (JP)
NAKANO TAKAYUKI (JP)
KO NORIOKI (JP)
HASHIMOTO FUMIO (JP)
Application Number:
PCT/JP2006/313197
Publication Date:
January 04, 2007
Filing Date:
June 27, 2006
Export Citation:
Assignee:
UNIV KAGOSHIMA (JP)
TOTSUKAWANOUJOU CORP (JP)
SAKATA YUSUKE (JP)
FUJII MAKOTO (JP)
NAKANO TAKAYUKI (JP)
KO NORIOKI (JP)
HASHIMOTO FUMIO (JP)
TOTSUKAWANOUJOU CORP (JP)
SAKATA YUSUKE (JP)
FUJII MAKOTO (JP)
NAKANO TAKAYUKI (JP)
KO NORIOKI (JP)
HASHIMOTO FUMIO (JP)
International Classes:
A61K36/73; A23L1/30; A23L2/38; A61P3/06; A61P3/10; A61P9/12; A61P35/00; A61P39/06
Domestic Patent References:
| WO2006013866A1 | 2006-02-09 |
Foreign References:
| JP2006104182A | 2006-04-20 | |||
| JP2000342229A | 2000-12-12 | |||
| JP2002193734A | 2002-07-10 |
Other References:
KWON H.J.: "Inhibition of NFkappaB by methyl chlorogenate from Eriobotrya japonica", MOLECULES AND CELLS, vol. 10, no. 3, 2000, pages 241 - 246, XP003007329
TANIGUCHI S. ET AL.: "Production of bioactive triterpenes by Eriobotrya japonica calli", PHYTOCHEMISTRY, vol. 59, no. 3, 2002, pages 315 - 323, XP004335024
JUNG H.A. ET AL.: "Antioxidant flavonoids and chlorogenic acid from the leaves of Eriobotrya japonica", ARCHIVES OF PHARMACAL RESEARCH, vol. 22, no. 2, 1999, pages 213 - 218, XP000999853
ITO H. ET AL.: "Antitumor activity of compounds isolated from leaves of Eriobotrya japonica", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 50, no. 8, 2002, pages 2400 - 2403, XP002994313
YOUNG H.-S. ET AL.: "Antitumor effects of ursolic acid isolated from the leaves of Eriobotrya japonica", NAUTRAL MEDICINES, vol. 49, no. 2, 1995, pages 190 - 192, XP003007330
ITO H. ET AL.: "Polyphenols from Erioborya japonica and their cytotoxicity against human oral tumor cell lines", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 48, no. 5, 2000, pages 687 - 693, XP002979343
TANAKA K. ET AL.: "Bancha Shoyo to Biwaha no Junen Kako ni yoru Hakkocha no Tonyobyo Yobo Koka", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE SOKAI KOEN YOSHISHU, vol. 59TH, 1 April 2005 (2005-04-01), pages 144, XP003007331
SAKURAMATA Y. ET AL.: "Anti-diabetic effects of combination of white skinned sweet potato (Ipomoea batatas L.) with loquat leaf extract)", J. TRADIT. MED., vol. 21, no. 5, 2004, pages 237 - 240, XP003007332
NOZATO N. ET AL.: "Triterpenes from the leaves of Eriobotrya japonica", NATURAL MEDICINES, vol. 48, no. 4, 1994, pages 336, XP003007333
TANIGUCHI S. ET AL.: "Production of bioactive triterpenes by Eriobotrya japonica calli", PHYTOCHEMISTRY, vol. 59, no. 3, 2002, pages 315 - 323, XP004335024
JUNG H.A. ET AL.: "Antioxidant flavonoids and chlorogenic acid from the leaves of Eriobotrya japonica", ARCHIVES OF PHARMACAL RESEARCH, vol. 22, no. 2, 1999, pages 213 - 218, XP000999853
ITO H. ET AL.: "Antitumor activity of compounds isolated from leaves of Eriobotrya japonica", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 50, no. 8, 2002, pages 2400 - 2403, XP002994313
YOUNG H.-S. ET AL.: "Antitumor effects of ursolic acid isolated from the leaves of Eriobotrya japonica", NAUTRAL MEDICINES, vol. 49, no. 2, 1995, pages 190 - 192, XP003007330
ITO H. ET AL.: "Polyphenols from Erioborya japonica and their cytotoxicity against human oral tumor cell lines", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 48, no. 5, 2000, pages 687 - 693, XP002979343
TANAKA K. ET AL.: "Bancha Shoyo to Biwaha no Junen Kako ni yoru Hakkocha no Tonyobyo Yobo Koka", THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE SOKAI KOEN YOSHISHU, vol. 59TH, 1 April 2005 (2005-04-01), pages 144, XP003007331
SAKURAMATA Y. ET AL.: "Anti-diabetic effects of combination of white skinned sweet potato (Ipomoea batatas L.) with loquat leaf extract)", J. TRADIT. MED., vol. 21, no. 5, 2004, pages 237 - 240, XP003007332
NOZATO N. ET AL.: "Triterpenes from the leaves of Eriobotrya japonica", NATURAL MEDICINES, vol. 48, no. 4, 1994, pages 336, XP003007333
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
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