Title:
PHARMACEUTICAL AND FOOD COMPOSITION FOR PREVENTING OR TREATING DIABETES OR OBESITY
Document Type and Number:
WIPO Patent Application WO/2012/046945
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical and food composition for preventing or treating diabetes or obesity, and more particularly, to a pharmaceutical composition and functional food for preventing or treating diabetes or obesity and which contain, as active ingredients, novel compounds synthesized from compounds separated from extracts of Stereocaulon alpinum, which is an Antarctic lichen. The novel compounds of the present invention have an excellent activity of inhibiting protein tyrosine phosphatase-1b (PTP-1b), may selectively influence only PTP-1b from among protein tyrosine phosphatases, and may be used as a substantial PTP-1b inhibitor in treating diabetes, and thus may be effectively used in preventing or treating diabetes and obesity.
Inventors:
YIM JONG HAN (KR)
KIM IL CHAN (KR)
KIM DOC KYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
KIM JUNG EUN (KR)
KIM TAI KYOUNG (KR)
OH HYUN CHEOL (KR)
JO DONG-GYU (KR)
LEE CHEOLSOON (KR)
KIM KEUN-SIK (KR)
LEE PYUNG CHEON (KR)
PARK MI RA (KR)
PARK YU-KYUNG (KR)
KIM SUNG JIN (KR)
KANG PIL-SUNG (KR)
PARK HEEYONG (KR)
PARK HA JU (KR)
KIM IL CHAN (KR)
KIM DOC KYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
KIM JUNG EUN (KR)
KIM TAI KYOUNG (KR)
OH HYUN CHEOL (KR)
JO DONG-GYU (KR)
LEE CHEOLSOON (KR)
KIM KEUN-SIK (KR)
LEE PYUNG CHEON (KR)
PARK MI RA (KR)
PARK YU-KYUNG (KR)
KIM SUNG JIN (KR)
KANG PIL-SUNG (KR)
PARK HEEYONG (KR)
PARK HA JU (KR)
Application Number:
PCT/KR2011/004836
Publication Date:
June 14, 2012
Filing Date:
July 01, 2011
Export Citation:
Assignee:
KOREA OCEAN RES AND DEV INSITUTE (KR)
YIM JONG HAN (KR)
KIM IL CHAN (KR)
KIM DOC KYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
KIM JUNG EUN (KR)
KIM TAI KYOUNG (KR)
OH HYUN CHEOL (KR)
JO DONG-GYU (KR)
LEE CHEOLSOON (KR)
KIM KEUN-SIK (KR)
LEE PYUNG CHEON (KR)
PARK MI RA (KR)
PARK YU-KYUNG (KR)
KIM SUNG JIN (KR)
KANG PIL-SUNG (KR)
PARK HEEYONG (KR)
PARK HA JU (KR)
YIM JONG HAN (KR)
KIM IL CHAN (KR)
KIM DOC KYU (KR)
HAN SE JONG (KR)
LEE HYOUNG SEOK (KR)
HARI DATTA BHATTARAI (KR)
KIM JUNG EUN (KR)
KIM TAI KYOUNG (KR)
OH HYUN CHEOL (KR)
JO DONG-GYU (KR)
LEE CHEOLSOON (KR)
KIM KEUN-SIK (KR)
LEE PYUNG CHEON (KR)
PARK MI RA (KR)
PARK YU-KYUNG (KR)
KIM SUNG JIN (KR)
KANG PIL-SUNG (KR)
PARK HEEYONG (KR)
PARK HA JU (KR)
International Classes:
A61K31/357; A61K31/343; A61P3/04; A61P3/10; C07D307/88
Foreign References:
| US20090048332A1 | 2009-02-19 | |||
| US20090143279A1 | 2009-06-04 |
Other References:
SEO, C. ET AL.: "Protein tyrosine phosphatase 1B inhibitory effects of depsidone and pseudodepsidone metabolites from the Antarctic lichen Stereocaulon alpinum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 10, 2009, pages 2801 - 2803, XP026085971
Attorney, Agent or Firm:
LEE, Cheo Young (Yeosam Bldg. 648-23,Yeoksam-dong, Gangnam-gu, Seoul 135-080, KR)
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Claims: