Title:
PHARMACEUTICAL FORMULATIONS WITH LOW AQUEOUS LEVELS OF FREE UNBOUND DRUG
Document Type and Number:
WIPO Patent Application WO/2010/148288
Kind Code:
A3
Abstract:
The complexation properties of cyclodextrins are combined with the partitioning properties of reversed lyotropic liquid crystalline phase microparticles to prepare pharmaceutical formulation dispersions with reduced levels of free unbound aqueous drug. Safe to inject formulations including, for example, propofol, include dispersions of reversed lyotropic liquid crystalline phase microparticles with propofol in an aqueous carrier together with cyclodextrins.
Inventors:
ANDERSON DAVID M (US)
Application Number:
PCT/US2010/039139
Publication Date:
May 19, 2011
Filing Date:
June 18, 2010
Export Citation:
Assignee:
LYOTROPIC THERAPEUTICS INC (US)
ANDERSON DAVID M (US)
ANDERSON DAVID M (US)
International Classes:
A61K47/40; A61K9/16; A61K9/20; A61K31/05
Foreign References:
| KR20060130646A | 2006-12-19 | |||
| JP2001058994A | 2001-03-06 | |||
| US20020012680A1 | 2002-01-31 | |||
| US20040014718A1 | 2004-01-22 | |||
| US20060140895A1 | 2006-06-29 |
Other References:
DAVID C. WARLTIER, PROPOFOL. ANESTHESIOLOGY., vol. 103, no. 4, October 2005 (2005-10-01), pages 860 - 87 6
Attorney, Agent or Firm:
WHITHAM, Michael, E. et al. (Curtis Christofferson & Cook, P.C.,11491 Sunset Hills Road,Suite 34, Reston VA, US)
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