Title:
PHARMACEUTICAL FORMULATIONS
Document Type and Number:
WIPO Patent Application WO1990003164
Kind Code:
A3
Abstract:
Orally or rectally administrable formulations of biologically active material comprise a water-in-oil microemulsion, wherein the hydrophilic phase of the microemulsion comprises the biologically active material and the hydrophobic phase comprises chylomicra or material capable of forming chylomicra in the intestinal mucosa after administration. The biologically active material may be any of a wide range of substances including insulin, calcitonin and somatotrophin or growth hormone. Formulations of the invention are particularly suitable for the oral administration of insulin in the treatment of diabetes.
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Inventors:
CHO YOUNG W (US)
FLYNN MICHAEL JOHN (US)
FLYNN MICHAEL JOHN (US)
Application Number:
PCT/GB1989/001161
Publication Date:
June 14, 1990
Filing Date:
September 29, 1989
Export Citation:
Assignee:
PATRALAN LTD (GB)
CHO YOUNG W (GB)
FLYNN MICHAEL JOHN (GB)
CHO YOUNG W (GB)
FLYNN MICHAEL JOHN (GB)
International Classes:
A61K9/107; A61K9/127; A61K9/16; A61K9/50; A61K35/16; A61K38/00; A61K38/21; A61K38/23; A61K38/27; A61K38/28; A61K38/36; A61K38/49; B05C5/02; (IPC1-7): A61K9/107; A61K9/127; A61K35/16; A61K37/00
Domestic Patent References:
| WO1989000812A1 | 1989-02-09 | |||
| WO1988006881A1 | 1988-09-22 |
Foreign References:
| US4146499A | 1979-03-27 | |||
| EP0140085A2 | 1985-05-08 | |||
| FR2455458A1 | 1980-11-28 | |||
| US4536324A | 1985-08-20 | |||
| EP0277776A2 | 1988-08-10 | |||
| GB2085729A | 1982-05-06 | |||
| FR2581543A1 | 1986-11-14 |
Other References:
PATENT ABSTRACTS OF JAPAN, Volume 6, No. 154 (C-119) (1032), 14 August 1982; & JP-A-5772920 (Toyama Kagaku Kogyo K.K.) 7 May 1982
PATENT ABSTRACTS OF JAPAN, Volume 10, No. 239 (C-367) (2295), 19 August 1986; & JP-A-6172721 (Daigo Eiyou Kagaku K.K.) 14 April 1986
PATENT ABSTRACTS OF JAPAN, Volume 7, No. 97 (C-163) (1242), 23 April 1983; & JP-A-5821622 (Kouwa K.K.) 8 February 1983
PATENT ABSTRACTS OF JAPAN, Volume 10, No. 239 (C-367) (2295), 19 August 1986; & JP-A-6172721 (Daigo Eiyou Kagaku K.K.) 14 April 1986
PATENT ABSTRACTS OF JAPAN, Volume 7, No. 97 (C-163) (1242), 23 April 1983; & JP-A-5821622 (Kouwa K.K.) 8 February 1983
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