Title:
PHARMACEUTICAL, KIT, AND SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/219164
Kind Code:
A1
Abstract:
This pharmaceutical is used in a method including a step A for administering a bubble to a mammal and irradiating a target region in the mammal with ultrasound, and a step B for administering a composite to the mammal. The pharmaceutical contains the composite, and the composite includes a polymer and a substance that forms a composite with the polymer.
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Inventors:
KINOH HIROAKI (JP)
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
HONDA YUTO (JP)
NAGAO SHUHEI (JP)
NOMOTO TAKAHIRO (JP)
KATAOKA KAZUNORI (JP)
NISHIYAMA NOBUHIRO (JP)
HONDA YUTO (JP)
NAGAO SHUHEI (JP)
NOMOTO TAKAHIRO (JP)
Application Number:
PCT/JP2023/017950
Publication Date:
November 16, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
KAWASAKI INST OF INDUSTRIAL PROMOTION (JP)
International Classes:
A61K9/12; A61K9/127; A61K35/76; A61K47/30; A61N7/00; A61P25/00; A61P35/00; C12M1/42; C12N15/864; C12N15/88
Domestic Patent References:
| WO2020241819A1 | 2020-12-03 |
Other References:
ENDO-TAKAHASHI YOKO, KUROKAWA RYO, SATO KANAKO, TAKIZAWA NAO, KATAGIRI FUMIHIKO, HAMANO NOBUHITO, SUZUKI RYO, MARUYAMA KAZUO, NOMI: "Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound", PHARMACEUTICS, MDPI AG, CH, vol. 13, no. 7, CH , pages 1003, XP093108954, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics13071003
YAO LEI; SONG QINGXIANG; BAI WENKUN; ZHANG JIZHEN; MIAO DEYU; JIANG MENGYIN; WANG YU; SHEN ZHIYONG; HU QUANYIN; GU XIAO; HUANG MEN: "Facilitated brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultras", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 10, 18 January 2014 (2014-01-18), AMSTERDAM, NL , pages 3384 - 3395, XP028822046, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2013.12.043
FISHMAN PAUL S., FISCHELL JONATHAN M.: "Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases", FRONTIERS IN NEUROLOGY, vol. 12, XP093108955, ISSN: 1664-2295, DOI: 10.3389/fneur.2021.749047
FOIRET JOSQUIN; ZHANG HUA; FITE BRETT Z.; ILOVITSH TALI; MAHAKIAN LISA M.; TAM SARAH; BEITNERE ULRIKA; PYLES BENJAMIN; SEGAL DAVID: "Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study", 2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), IEEE, 6 September 2017 (2017-09-06), pages 1 - 4, XP033245348, DOI: 10.1109/ULTSYM.2017.8092207
OMATA DAIKI, MUNAKATA LISA, MARUYAMA KAZUO, SUZUKI RYO: "Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 44, no. 10, 1 October 2021 (2021-10-01), JP , pages 1391 - 1398, XP093108959, ISSN: 0918-6158, DOI: 10.1248/bpb.b21-00453
YAO LEI; SONG QINGXIANG; BAI WENKUN; ZHANG JIZHEN; MIAO DEYU; JIANG MENGYIN; WANG YU; SHEN ZHIYONG; HU QUANYIN; GU XIAO; HUANG MEN: "Facilitated brain delivery of poly (ethylene glycol)–poly (lactic acid) nanoparticles by microbubble-enhanced unfocused ultras", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 10, 18 January 2014 (2014-01-18), AMSTERDAM, NL , pages 3384 - 3395, XP028822046, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2013.12.043
FISHMAN PAUL S., FISCHELL JONATHAN M.: "Focused Ultrasound Mediated Opening of the Blood-Brain Barrier for Neurodegenerative Diseases", FRONTIERS IN NEUROLOGY, vol. 12, XP093108955, ISSN: 1664-2295, DOI: 10.3389/fneur.2021.749047
FOIRET JOSQUIN; ZHANG HUA; FITE BRETT Z.; ILOVITSH TALI; MAHAKIAN LISA M.; TAM SARAH; BEITNERE ULRIKA; PYLES BENJAMIN; SEGAL DAVID: "Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study", 2017 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS), IEEE, 6 September 2017 (2017-09-06), pages 1 - 4, XP033245348, DOI: 10.1109/ULTSYM.2017.8092207
OMATA DAIKI, MUNAKATA LISA, MARUYAMA KAZUO, SUZUKI RYO: "Enhanced Vascular Permeability by Microbubbles and Ultrasound in Drug Delivery", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 44, no. 10, 1 October 2021 (2021-10-01), JP , pages 1391 - 1398, XP093108959, ISSN: 0918-6158, DOI: 10.1248/bpb.b21-00453
Attorney, Agent or Firm:
OIKAWA Shu et al. (JP)
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