PHARMACEUTICAL PREPARATION HAVING EXCELLENT PHOTOSTABILITY AND DRUG RELEASE PROPERTIES

Title:

PHARMACEUTICAL PREPARATION HAVING EXCELLENT PHOTOSTABILITY AND DRUG RELEASE PROPERTIES

Document Type and Number:

WIPO Patent Application WO/2019/098259

Kind Code:

A1

Abstract:

The present invention provides a preparation which remains substantially uncolored even when irradiated with light, by coating a preparation containing the compound represented by formula (I), a salt of said compound, or a crystal of these compounds with a photostable substance and a polymer molecule, using, in particular, at least one substance from among titanium oxide and talc as the photostable substance and hypromellose as the polymer molecule.

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Inventors:

HAYASHI NAOMI (JP)
GOMI MASATO (JP)
AIKAWA SHOHEI (JP)

Application Number:

PCT/JP2018/042220

Publication Date:

May 23, 2019

Filing Date:

November 15, 2018

Export Citation:

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Assignee:

SHIONOGI & CO (JP)

International Classes:

A61K31/5383; A61K9/16; A61K9/20; A61K9/28; A61K47/02; A61K47/32; A61K47/38; A61P31/16; A61P43/00; C07D498/14; G01N30/88

Domestic Patent References:

WO2016175224A1	2016-11-03
WO2008114859A1	2008-09-25
WO2016204291A1	2016-12-22
WO2016175224A1	2016-11-03
WO2002060446A1	2002-08-08
WO2007052592A1	2007-05-10
WO2004052342A1	2004-06-24
WO2012144592A1	2012-10-26

Foreign References:

JP2015054851A	2015-03-23
JP2014513714A	2014-06-05
JP2008201712A	2008-09-04
JP2015054822A	2015-03-23
JP2014193898A	2014-10-09
JP2013014610A	2013-01-24
JP2010270112A	2010-12-02

Other References:

BAERTSCHI, STEVEN W. ET AL.: "A Critical Assessment of the ICH Guideline on Photostability Testing of New Drug Substances and Products(Q1B):Recommendation for Revision", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99, no. 7, 2010, pages 2934 - 2940, XP055695822, ISSN: 0022-3549
THOMA, K. ET AL.: "Photostabilization of drugs in dosage forms without protection from packaging materials", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 67, 2, 1991, pages 169 - 175, XP025557819, ISSN: 0378-5173, DOI: 10.1016/0378-5173(91)90429-R
See also references of EP 3711767A4

Attorney, Agent or Firm:

SUGITA Ken-ichi et al. (JP)

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