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Patent Searching and Data


Title:
PHARMACEUTICAL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2019/167183
Kind Code:
A1
Abstract:
Provided is a pharmaceutical preparation that contains an aqueous composition containing an isoquinoline-6-amino derivative such as netarsudil or verosudil, and is nevertheless stable even at high temperature. This pharmaceutical preparation is obtained by housing, in a transparent container made of at least one resin selected from the group consisting of polyolefin resins and polyester resins, an aqueous composition containing a compound represented by general formula (1) (in the formula, R1 and R2 each independently represent a hydrogen atom or a C1-C4 alkyl group, R3 represents a hydrogen atom or a hydroxy group, A represents -CH(R4)- or -CH2-CH(R4)- (where R4 represents an optionally substituted C6-C10 aryl group or an optionally substituted 5- to 10-membered heteroaryl group), and in formula (1), a tautomer thereof is also included) or a salt thereof, or a solvate thereof.

Inventors:
YAMAKITA YOSHIHIRO (JP)
Application Number:
PCT/JP2018/007584
Publication Date:
September 06, 2019
Filing Date:
February 28, 2018
Export Citation:
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Assignee:
KOWA CO (JP)
International Classes:
A61J1/05; A61K31/472; A61K9/08; A61K31/4725; A61K47/04; A61K47/10; A61P27/02; A61P27/06; B65D1/00; B65D65/20
Domestic Patent References:
WO2016047720A12016-03-31
WO2005087237A12005-09-22
Foreign References:
JP2016515520A2016-05-30
JP2016138085A2016-08-04
Other References:
"RHOPRESSA? (netarsudil ophthalmic solution) Label, NDA 208254", HOW SUPPLIED/STORAGE AND HANDLING, December 2017 (2017-12-01), pages 4 - 10
ELLIS, E. M. ET AL.: "Ocular hypotensive effect of the novel EP 3/FP agonist ONO-9054 versus Xalatan: results of a 28-day, double-masked, randomised study", BRITISH JOURNAL OF OPHTHALMOLOGY, vol. 101, no. 6, 20 September 2016 (2016-09-20), pages 796 - 800, XP055538363, ISSN: 1468-2079
LEVY, B. ET AL.: "Ocular hypotensive safety and systemic absorption of AR -13324 ophthalmic solution in normal volunteers", AMERICAN JOURNAL OF OPHTHALMOLOGY, vol. 159, no. 5, May 2015 (2015-05-01), pages 980 - 985 .el, XP055554459, ISSN: 0002-9394, doi:10.1016/j.ajo.2015.01.026
REN, R. ET AL.: "Netarsudil increases outflow facility in human eyes through multiple mechanisms", INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE, vol. 57, no. 14, November 2016 (2016-11-01), pages 6197 - 6209, XP055538365, ISSN: 1552-5783, doi:10.1167/iovs.16-20189
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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