Title:
PHARMACEUTICAL PRODUCT CONTAINING LACTAM OR BENZENE SULFONAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/007819
Kind Code:
A1
Abstract:
Disclosed is a compound represented by formula (I) or the like, which is used as an agent for treatment of diseases that are induced by the production, secretion or deposition of amyloid β protein.
Specifically disclosed is a pharmaceutical composition for inhibiting the production of amyloid β protein, which contains a compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt. (In the formula, A represents a benzene ring, a pyridine ring or a pyrimidine ring; X represents a sultam group, a lactam group, a sulfoneamide group or the like; C represents a substituted or unsubstituted imidazolyl group, a substituted or unsubstituted oxazolyl group or the like; and R2, R3 and R4 each independently represents a hydrogen atom, a halogen atom, a hydroxy group, a carboxy group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group or the like.)
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Inventors:
KATO ISSEI (JP)
KANO KAZUYA (JP)
KANO KAZUYA (JP)
Application Number:
PCT/JP2010/061947
Publication Date:
January 20, 2011
Filing Date:
July 15, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
KATO ISSEI (JP)
KANO KAZUYA (JP)
KATO ISSEI (JP)
KANO KAZUYA (JP)
International Classes:
C07D233/61; A61K31/4164; A61K31/4178; A61K31/42; A61K31/421; A61K31/422; A61K31/427; A61K31/428; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/5377; A61K31/541; A61K31/635; A61P25/28; A61P43/00; C07D261/08; C07D263/32; C07D401/04; C07D401/12; C07D403/10; C07D403/12; C07D409/12; C07D413/12; C07D417/10; C07D417/12; C07D487/04
Domestic Patent References:
WO2008137102A2 | 2008-11-13 | |||
WO2007135969A1 | 2007-11-29 | |||
WO2005032468A2 | 2005-04-14 | |||
WO2009137657A1 | 2009-11-12 | |||
WO2009020579A1 | 2009-02-12 | |||
WO2008097538A1 | 2008-08-14 | |||
WO2009052126A1 | 2009-04-23 | |||
WO2009075874A1 | 2009-06-18 | |||
WO2009076337A1 | 2009-06-18 | |||
WO2005115990A1 | 2005-12-08 | |||
WO2008137102A2 | 2008-11-13 | |||
WO2007135969A1 | 2007-11-29 | |||
WO2007088895A1 | 2007-08-09 | |||
WO2003087071A1 | 2003-10-23 | |||
WO1999032475A1 | 1999-07-01 | |||
WO2003062241A1 | 2003-07-31 | |||
WO2002067939A1 | 2002-09-06 | |||
WO2002024702A1 | 2002-03-28 | |||
WO2008103636A1 | 2008-08-28 | |||
WO2006122806A2 | 2006-11-23 | |||
WO2007123853A2 | 2007-11-01 | |||
WO2007089857A2 | 2007-08-09 | |||
WO2009133861A1 | 2009-11-05 | |||
WO2008086188A2 | 2008-07-17 | |||
WO2007007588A1 | 2007-01-18 | |||
WO2006069946A1 | 2006-07-06 | |||
WO2005044192A2 | 2005-05-19 |
Foreign References:
JPH11504624A | 1999-04-27 | |||
US20040077606A1 | 2004-04-22 | |||
US20030114420A1 | 2003-06-19 | |||
US7199149B2 | 2007-04-03 | |||
DE1016717B | 1957-10-03 |
Other References:
SMALLHEER, JOANNE M. ET AL.: "Sulfonamidolactam inhibitors of coagulation factor", XA BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 7, 2008, pages 2428 - 2433, XP022574976
YOUNG, ROBERT J. ET AL.: "Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 28 - 33, XP022410851
YOUNG, ROBERT J. ET AL.: "Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 23 - 27, XP022410850
DATABASE CHEMCATS [online] XP008149716, accession no. stn Database accession no. 779926
DATABASE CHEMCATS [online] XP008149715, accession no. STN Database accession no. 779923
DATABASE CHEMCATS [online] accession no. STN Database accession no. 779924
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 10, 2007, pages 2817 - 2822
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 1, 2009, pages 230 - 233
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 71, no. 11, 1994, pages 693 - 5
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 6, 2008, pages 1910 - 1915
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 5, 1992, pages 461 - 6
BULLETIN OF THE FACULTY OF PHARMACY, vol. 33, pages 25 - 8
"Labeled Compounds (Part A", vol. 1, 1987, article "Isotopes in the Physical and Biomedical Sciences"
ORGANIC REACTION, vol. 14, 1965, pages 270
YOUNG, ROBERT J. ET AL.: "Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 28 - 33, XP022410851
YOUNG, ROBERT J. ET AL.: "Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 1, 2008, pages 23 - 27, XP022410850
DATABASE CHEMCATS [online] XP008149716, accession no. stn Database accession no. 779926
DATABASE CHEMCATS [online] XP008149715, accession no. STN Database accession no. 779923
DATABASE CHEMCATS [online] accession no. STN Database accession no. 779924
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 10, 2007, pages 2817 - 2822
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 1, 2009, pages 230 - 233
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, vol. 71, no. 11, 1994, pages 693 - 5
BIOORGANIC&MEDICINAL CHEMISTRY LETTERS, vol. 18, no. 6, 2008, pages 1910 - 1915
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 5, 1992, pages 461 - 6
BULLETIN OF THE FACULTY OF PHARMACY, vol. 33, pages 25 - 8
"Labeled Compounds (Part A", vol. 1, 1987, article "Isotopes in the Physical and Biomedical Sciences"
ORGANIC REACTION, vol. 14, 1965, pages 270
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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