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Title:
PHARMACEUTICAL PRODUCT FOR LOWERING BLOOD LDL
Document Type and Number:
WIPO Patent Application WO/2014/017569
Kind Code:
A1
Abstract:
A pharmaceutical product for lowering blood LDL, which is a pharmaceutical product that contains a compound represented by formula (I) as an active ingredient, said compound having actions of inhibiting the expression of PCSK9mRNA, lowering the amount of PCSK9 protein, and increasing the amount of an LDL receptor. (In formula (I), R1 represents a hydrogen atom, a hydroxyl group, a C1-6 alkoxy group or the like; R represents a C1-6 alkyl group or the like; the ring structure Q represents a phenyl group or a monocyclic or bicyclic heterocyclic ring; and each of R2 and R3 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-8 cycloalkyl C1-6 alkyl group or the like.)

Inventors:
OHGIYA TADAAKI (JP)
YAMAZAKI KOICHI (JP)
MATSUDA KENNOSUKE (JP)
WATANABE TOSHIAKI (JP)
MAEJIMA TAKASHI (JP)
Application Number:
PCT/JP2013/070128
Publication Date:
January 30, 2014
Filing Date:
July 25, 2013
Export Citation:
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Assignee:
KOWA CO (JP)
International Classes:
A61K31/505; A61K31/506; A61K31/513; A61K31/5377; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/12; A61P13/08; A61P13/12; A61P17/06; A61P19/00; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P33/00; A61P35/00; A61P43/00; C07D239/47; C07D401/12; C07D403/12; C07D413/12; C07D471/04
Domestic Patent References:
WO2012046681A12012-04-12
WO2007088996A12007-08-09
WO2007088999A12007-08-09
WO2008129951A12008-10-30
WO2008111604A12008-09-18
WO2008018529A12008-02-14
WO2006098394A12006-09-21
WO2013046045A12013-04-04
WO2013024358A22013-02-21
WO2013008164A22013-01-17
Foreign References:
JP2010077116A2010-04-08
JP2009051828A2009-03-12
JP2009051827A2009-03-12
JP2009536172A2009-10-08
JP2009524579A2009-07-02
JP2009524577A2009-07-02
JP2009522224A2009-06-11
JP2008528447A2008-07-31
JP2007506646A2007-03-22
JP2004323504A2004-11-18
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
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